Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein and by bacterial lipopolysaccharide (LPS) in a CD14-depende...

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Detalles Bibliográficos
Autores principales: Rallabhandi, Prasad, Phillips, Rachel L., Boukhvalova, Marina S., Pletneva, Lioubov M., Shirey, Kari Ann, Gioannini, Theresa L., Weiss, Jerrold P., Chow, Jesse C., Hawkins, Lynn D., Vogel, Stefanie N., Blanco, Jorge C. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419526/
https://www.ncbi.nlm.nih.gov/pubmed/22872782
http://dx.doi.org/10.1128/mBio.00218-12

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