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Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice

Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latenc...

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Autores principales: Amat, Nurmuhammat, Hoxur, Parida, Ming, Dang, Matsidik, Aynur, Kijjoa, Anake, Upur, Halmurat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419564/
https://www.ncbi.nlm.nih.gov/pubmed/22919413
http://dx.doi.org/10.1155/2012/426757
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author Amat, Nurmuhammat
Hoxur, Parida
Ming, Dang
Matsidik, Aynur
Kijjoa, Anake
Upur, Halmurat
author_facet Amat, Nurmuhammat
Hoxur, Parida
Ming, Dang
Matsidik, Aynur
Kijjoa, Anake
Upur, Halmurat
author_sort Amat, Nurmuhammat
collection PubMed
description Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latency time in the step-through test and the decrease of the latency time in the Y-maze test. Treatment with ASMq was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and β-endorphin (β-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ASMq was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT) and 3,4-dihydroxyphenylalanine (DOPAC). The results obtained from this study suggested that the memory-enhancing effect of ASMq was mediated through regulations of neurochemical and neuroendocrine systems.
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spelling pubmed-34195642012-08-23 Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice Amat, Nurmuhammat Hoxur, Parida Ming, Dang Matsidik, Aynur Kijjoa, Anake Upur, Halmurat Evid Based Complement Alternat Med Research Article Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latency time in the step-through test and the decrease of the latency time in the Y-maze test. Treatment with ASMq was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and β-endorphin (β-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ASMq was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT) and 3,4-dihydroxyphenylalanine (DOPAC). The results obtained from this study suggested that the memory-enhancing effect of ASMq was mediated through regulations of neurochemical and neuroendocrine systems. Hindawi Publishing Corporation 2012 2012-08-02 /pmc/articles/PMC3419564/ /pubmed/22919413 http://dx.doi.org/10.1155/2012/426757 Text en Copyright © 2012 Nurmuhammat Amat et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Amat, Nurmuhammat
Hoxur, Parida
Ming, Dang
Matsidik, Aynur
Kijjoa, Anake
Upur, Halmurat
Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice
title Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice
title_full Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice
title_fullStr Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice
title_full_unstemmed Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice
title_short Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice
title_sort behavioral, neurochemical and neuroendocrine effects of abnormal savda munziq in the chronic stress mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419564/
https://www.ncbi.nlm.nih.gov/pubmed/22919413
http://dx.doi.org/10.1155/2012/426757
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