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Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity

BACKGROUND: Gain-of-function mutations of tyrosine kinase FLT3 are frequently found in acute myeloid leukemia (AML). This has made FLT3 an important marker for disease diagnosis and a highly attractive target for therapeutic drug development. This study is intended to generate a sensitive substrate...

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Detalles Bibliográficos
Autores principales:	Chen, Yun, Guo, Yao, Han, Jiayu, Ho, Wanting Tina, Li, Shibo, Fu, Xueqi, Zhao, Zhizhuang Joe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419602/ https://www.ncbi.nlm.nih.gov/pubmed/22800464 http://dx.doi.org/10.1186/1756-8722-5-39

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