From loss to gain: role for SUN1 in laminopathies

Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomit...

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Detalles Bibliográficos
Autores principales: Liu, Baohua, Jin, Dong-Yan, Zhou, Zhongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419603/
https://www.ncbi.nlm.nih.gov/pubmed/22709970
http://dx.doi.org/10.1186/2045-3701-2-21
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author Liu, Baohua
Jin, Dong-Yan
Zhou, Zhongjun
author_facet Liu, Baohua
Jin, Dong-Yan
Zhou, Zhongjun
author_sort Liu, Baohua
collection PubMed
description Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomitantly suggests a gain-of-function versus a loss-of-function model for the action of lamin A mutants.
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spelling pubmed-34196032012-08-16 From loss to gain: role for SUN1 in laminopathies Liu, Baohua Jin, Dong-Yan Zhou, Zhongjun Cell Biosci Research Highlight Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomitantly suggests a gain-of-function versus a loss-of-function model for the action of lamin A mutants. BioMed Central 2012-06-18 /pmc/articles/PMC3419603/ /pubmed/22709970 http://dx.doi.org/10.1186/2045-3701-2-21 Text en Copyright ©2012 Liu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Highlight
Liu, Baohua
Jin, Dong-Yan
Zhou, Zhongjun
From loss to gain: role for SUN1 in laminopathies
title From loss to gain: role for SUN1 in laminopathies
title_full From loss to gain: role for SUN1 in laminopathies
title_fullStr From loss to gain: role for SUN1 in laminopathies
title_full_unstemmed From loss to gain: role for SUN1 in laminopathies
title_short From loss to gain: role for SUN1 in laminopathies
title_sort from loss to gain: role for sun1 in laminopathies
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419603/
https://www.ncbi.nlm.nih.gov/pubmed/22709970
http://dx.doi.org/10.1186/2045-3701-2-21
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