Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer’s disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the underlying molecular and cellular mechanisms...

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Detalles Bibliográficos
Autores principales: Russell, Claire L., Semerdjieva, Sophia, Empson, Ruth M., Austen, Brian M., Beesley, Philip W., Alifragis, Pavlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419646/
https://www.ncbi.nlm.nih.gov/pubmed/22905234
http://dx.doi.org/10.1371/journal.pone.0043201

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