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Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis
BACKGROUND: Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses. METHODOLOGY/PRINCIPAL FINDINGS: To estimate associations between BPA exposure and angiographi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419714/ https://www.ncbi.nlm.nih.gov/pubmed/22916252 http://dx.doi.org/10.1371/journal.pone.0043378 |
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author | Melzer, David Gates, Phil Osborn, Nicholas J. Henley, William E. Cipelli, Ricardo Young, Anita Money, Cathryn McCormack, Paul Schofield, Peter Mosedale, David Grainger, David Galloway, Tamara S. |
author_facet | Melzer, David Gates, Phil Osborn, Nicholas J. Henley, William E. Cipelli, Ricardo Young, Anita Money, Cathryn McCormack, Paul Schofield, Peter Mosedale, David Grainger, David Galloway, Tamara S. |
author_sort | Melzer, David |
collection | PubMed |
description | BACKGROUND: Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses. METHODOLOGY/PRINCIPAL FINDINGS: To estimate associations between BPA exposure and angiographically graded coronary atherosclerosis. 591 patients participating in The Metabonomics and Genomics in Coronary Artery Disease (MaGiCAD) study in Cambridgeshire UK, comparing urinary BPA (uBPA) with grades of severity of coronary artery disease (CAD) on angiography. Linear models were adjusted for BMI, occupational social class and diabetes status. Severe (one to three vessel) CAD was present in 385 patients, 86 had intermediate disease (n = 86) and 120 had normal coronary arteries. The (unadjusted) median uBPA concentration was 1.28 ng/mL with normal coronary arteries, and 1.53 ng/mL with severe CAD. Compared to those with normal coronary arteries, uBPA concentration was significantly higher in those with severe CAD (OR per uBPA SD = 5.96 ng/ml OR = 1.43, CI 1.03 to 1.98, p = 0.033), and near significant for intermediate disease (OR = 1.69, CI 0.98 to 2.94, p = 0.061). There was no significant uBPA difference between patients with severe CAD (needing surgery) and the remaining groups combined. CONCLUSIONS/SIGNIFICANCE: BPA exposure was higher in those with severe coronary artery stenoses compared to those with no vessel disease. Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established. |
format | Online Article Text |
id | pubmed-3419714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34197142012-08-22 Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis Melzer, David Gates, Phil Osborn, Nicholas J. Henley, William E. Cipelli, Ricardo Young, Anita Money, Cathryn McCormack, Paul Schofield, Peter Mosedale, David Grainger, David Galloway, Tamara S. PLoS One Research Article BACKGROUND: Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses. METHODOLOGY/PRINCIPAL FINDINGS: To estimate associations between BPA exposure and angiographically graded coronary atherosclerosis. 591 patients participating in The Metabonomics and Genomics in Coronary Artery Disease (MaGiCAD) study in Cambridgeshire UK, comparing urinary BPA (uBPA) with grades of severity of coronary artery disease (CAD) on angiography. Linear models were adjusted for BMI, occupational social class and diabetes status. Severe (one to three vessel) CAD was present in 385 patients, 86 had intermediate disease (n = 86) and 120 had normal coronary arteries. The (unadjusted) median uBPA concentration was 1.28 ng/mL with normal coronary arteries, and 1.53 ng/mL with severe CAD. Compared to those with normal coronary arteries, uBPA concentration was significantly higher in those with severe CAD (OR per uBPA SD = 5.96 ng/ml OR = 1.43, CI 1.03 to 1.98, p = 0.033), and near significant for intermediate disease (OR = 1.69, CI 0.98 to 2.94, p = 0.061). There was no significant uBPA difference between patients with severe CAD (needing surgery) and the remaining groups combined. CONCLUSIONS/SIGNIFICANCE: BPA exposure was higher in those with severe coronary artery stenoses compared to those with no vessel disease. Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established. Public Library of Science 2012-08-15 /pmc/articles/PMC3419714/ /pubmed/22916252 http://dx.doi.org/10.1371/journal.pone.0043378 Text en © 2012 Melzer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Melzer, David Gates, Phil Osborn, Nicholas J. Henley, William E. Cipelli, Ricardo Young, Anita Money, Cathryn McCormack, Paul Schofield, Peter Mosedale, David Grainger, David Galloway, Tamara S. Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis |
title | Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis |
title_full | Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis |
title_fullStr | Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis |
title_full_unstemmed | Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis |
title_short | Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis |
title_sort | urinary bisphenol a concentration and angiography-defined coronary artery stenosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419714/ https://www.ncbi.nlm.nih.gov/pubmed/22916252 http://dx.doi.org/10.1371/journal.pone.0043378 |
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