Cargando…

Efficacy of a Novel Class of RNA Interference Therapeutic Agents

RNA interference (RNAi) is being widely used in functional gene research and is an important tool for drug discovery. However, canonical double-stranded short interfering RNAs are unstable and induce undesirable adverse effects, and thus there is no currently RNAi-based therapy in the clinic. We hav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamasaki, Tomohiro, Suzuki, Hiroshi, Shirohzu, Hisao, Matsumoto, Takahiro, D'Alessandro-Gabazza, Corina N., Gil-Bernabe, Paloma, Boveda-Ruiz, Daniel, Naito, Masahiro, Kobayashi, Tetsu, Toda, Masaaki, Mizutani, Takayuki, Taguchi, Osamu, Morser, John, Eguchi, Yutaka, Kuroda, Masahiko, Ochiya, Takahiro, Hayashi, Hirotake, Gabazza, Esteban C., Ohgi, Tadaaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419724/ https://www.ncbi.nlm.nih.gov/pubmed/22916145 http://dx.doi.org/10.1371/journal.pone.0042655

Ejemplares similares

Eosinophils Promote Epithelial to Mesenchymal Transition of Bronchial Epithelial Cells
por: Yasukawa, Atsushi, et al.
Publicado: (2013)

Differential Gene Expression in Thrombomodulin (TM; CD141)(+) and TM(−) Dendritic Cell Subsets
por: Toda, Masaaki, et al.
Publicado: (2013)

Efficacy of osimertinib in a patient with non-small cell lung cancer harboring epithelial growth factor receptor exon 19 deletion/T790M mutation, with poor performance status
por: Nishii, Yoichi, et al.
Publicado: (2018)

Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial
por: Maruyama, Takaya, et al.
Publicado: (2010)

Activated protein C modulates the proinflammatory activity of dendritic cells
por: Matsumoto, Takahiro, et al.
Publicado: (2015)

Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
por: Sugimoto, Masahiko, et al.
Publicado: (2021)

Subcritical Water Extracts from Agaricus blazei Murrill’s Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor
por: Yasuma, Taro, et al.
Publicado: (2021)

Synthesis of (18)O-labeled RNA for application to kinetic studies and imaging
por: Hamasaki, Tomohiro, et al.
Publicado: (2013)

Culture Conditions for Mycelial Growth and Anti-Cancer Properties of Termitomyces
por: Tharavecharak, Suphachai, et al.
Publicado: (2023)

Control of HCV Replication With iMIRs, a Novel Anti-RNAi Agent
por: Itami, Saori, et al.
Publicado: (2015)

No Strong Evidence for Ruling Out the Role of Coagulation in Long-Term Disability after Critical Illness
por: Yasuma, Taro, et al.
Publicado: (2021)

Response of Lung Microbiota to Changes of Pulmonary Innate Immunity under Healthy Conditions
por: Yasuma, Taro, et al.
Publicado: (2021)

The Need for a CYFRA 21-1 Cutoff Value to Predict Clinical Progression of IPF in Clinical Practice
por: Fujimoto, Hajime, et al.
Publicado: (2022)

Microbial Burden-associated Cytokine Storm May Explain Nonresolving Acute Respiratory Distress Syndrome in Patients with COVID-19
por: Yasuma, Taro, et al.
Publicado: (2022)

Is the Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Ratio a Marker of Sonographic Septations in Pleural Infection?
por: Yasuma, Taro, et al.
Publicado: (2022)

Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus
por: Okano, Yuko, et al.
Publicado: (2021)

Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling
por: Kuwabara, Yu, et al.
Publicado: (2018)

Too Premature to Deny the Potential of Thrombomodulin Alfa in Idiopathic Pulmonary Fibrosis
por: Kobayashi, Tetsu, et al.
Publicado: (2020)

Renal Injury during Long-Term Crizotinib Therapy
por: Yasuma, Taro, et al.
Publicado: (2018)

β(2) adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells
por: Kainuma, Keigo, et al.
Publicado: (2017)

TNF-α is associated with loss of lean body mass only in already cachectic COPD patients
por: Eagan, Tomas ML, et al.
Publicado: (2012)

Degradation Products of Complex Arabinoxylans by Bacteroides intestinalis Enhance the Host Immune Response
por: Yasuma, Taro, et al.
Publicado: (2021)

A novel platform to enable inhaled naked RNAi medicine for lung cancer
por: Fujita, Yu, et al.
Publicado: (2013)

Terminal bridging of siRNA duplex at the ribose 2′ position controls strand bias and target sequence preference
por: Shibata, Atsushi, et al.
Publicado: (2023)

Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions
por: D’Alessandro, Valeria Fridman, et al.
Publicado: (2022)

Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping
por: D’Alessandro-Gabazza, Corina N., et al.
Publicado: (2018)

Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma
por: Takahashi, Yoshinori, et al.
Publicado: (2019)

Smart watch-based coaching with tiotropium and olodaterol ameliorates physical activity in patients with chronic obstructive pulmonary disease
por: Hataji, Osamu, et al.
Publicado: (2017)

Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis
por: Baffour Tonto, Prince, et al.
Publicado: (2019)

De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma
por: Fujiwara, Takumi, et al.
Publicado: (2020)

Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression
por: Inoue, Ryo, et al.
Publicado: (2023)

A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues
por: Saiki, Haruko, et al.
Publicado: (2021)

Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury
por: Fridman D'Alessandro, Valeria, et al.
Publicado: (2023)

A Retrospective Comparison of the Clinical Efficacy of Gefitinib, Erlotinib, and Afatinib in Japanese Patients With Non-Small Cell Lung Cancer
por: Fujiwara, Atsushi, et al.
Publicado: (2018)

Good Response of Advanced Thymic Carcinoma with Low PD-L1 Expression to Chemotherapy plus Pembrolizumab as First-Line Therapy and to Pembrolizumab as Maintenance Therapy: A Case Report
por: Nishii, Yoichi, et al.
Publicado: (2022)

Helicobacter pylori infection: is there circulating vacuolating cytotoxin A or cytotoxin-associated gene A protein?
por: Imoto, Ichiro, et al.
Publicado: (2022)

Three-dimensional computed tomography angiography for the preoperative evaluation of coronary artery disease in lung cancer patients
por: Watanabe, Fumiaki, et al.
Publicado: (2013)

Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis
por: Tanoue, Akiko, et al.
Publicado: (2021)

Factors leading to failure to diagnose pulmonary malignant tumors using endobronchial ultrasound with guide sheath within the target lesion
por: Nishii, Yoichi, et al.
Publicado: (2019)

Second‐line therapy with first‐ or second‐generation tyrosine kinase inhibitors in EGFR‐mutated non‐small cell lung cancer patients with T790M‐negative or unidentified mutation
por: Nishimura, Tadashi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l6lds858cc5v6o09dbvp6hssd1