Cargando…

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressive signaling pathways of EphA2 including inhibitio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petty, Aaron, Myshkin, Eugene, Qin, Haina, Guo, Hong, Miao, Hui, Tochtrop, Gregory P., Hsieh, Jer-Tsong, Page, Phillip, Liu, Lili, Lindner, Daniel J., Acharya, Chayan, MacKerell, Alexander D., Ficker, Eckhard, Song, Jianxing, Wang, Bingcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419725/ https://www.ncbi.nlm.nih.gov/pubmed/22916121 http://dx.doi.org/10.1371/journal.pone.0042120

Ejemplares similares

The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size
por: Zapata-Mercado, Elmer, et al.
Publicado: (2022)

EphA5 and EphA6: regulation of neuronal and spine morphology
por: Das, Gitanjali, et al.
Publicado: (2016)

Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival
por: Gajdzis, Malgorzata, et al.
Publicado: (2020)

Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
por: Chitramuthu, Babykumari, et al.
Publicado: (2016)

A Novel Occulta-Type Spina Bifida Mediated by Murine Double Heterozygotes EphA2 and EphA4 Receptor Tyrosine Kinases
por: Abdullah, Nor Linda, et al.
Publicado: (2017)

Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors
por: Hatano, Manabu, et al.
Publicado: (2004)

Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates
por: Udompholkul, Parima, et al.
Publicado: (2021)

EphA kinase activation regulates HGF-induced epithelial branching morphogenesis
por: Miao, Hui, et al.
Publicado: (2003)

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
por: Liang, Lung-Yu, et al.
Publicado: (2021)

Targeting EphA2 in cancer
por: Xiao, Ta, et al.
Publicado: (2020)

Therapeutic Targeting of Pancreatic Cancer via EphA2 Dimeric Agonistic Agents
por: Salem, Ahmed F., et al.
Publicado: (2020)

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia
por: Charmsaz, Sara, et al.
Publicado: (2015)

EphA1 receptor tyrosine kinase is localized to the nucleus in rhabdomyosarcoma from multiple species
por: LaCombe, Ronnie, et al.
Publicado: (2022)

Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations
por: Huan, Xuelu, et al.
Publicado: (2013)

Roles of EphA2 in Development and Disease
por: Park, Jeong Eun, et al.
Publicado: (2013)

The EphA1 and EphA2 Signaling Modulates the Epithelial Permeability in Human Sinonasal Epithelial Cells and the Rhinovirus Infection Induces Epithelial Barrier Dysfunction via EphA2 Receptor Signaling
por: Shin, Jae Min, et al.
Publicado: (2023)

Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer
por: Chang, Q, et al.
Publicado: (2008)

Dimerization of the EphA1 Receptor Tyrosine Kinase Transmembrane Domain: Insights into the Mechanism of Receptor Activation
por: Chavent, Matthieu, et al.
Publicado: (2014)

Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer
por: Staquicini, Fernanda I., et al.
Publicado: (2015)

EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells in vivo through Crosstalk with Akt and Regulates Stem Properties
por: Miao, Hui, et al.
Publicado: (2014)

EphA2 bears plasticity to tumor invasion
por: Sugiyama, Nami, et al.
Publicado: (2013)

Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model
por: Bhatia, Shilpa, et al.
Publicado: (2015)

Protein kinase A can block EphA2 receptor–mediated cell repulsion by increasing EphA2 S897 phosphorylation
por: Barquilla, Antonio, et al.
Publicado: (2016)

Development of an In-House EphA2 ELISA for Human Serum and Measurement of Circulating Levels of EphA2 in Hypertensive Patients with Renal Dysfunction
por: Murakoshi, Maki, et al.
Publicado: (2022)

Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells
por: Beuter, Simone, et al.
Publicado: (2016)

The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells
por: Shin, Won‐Sik, et al.
Publicado: (2020)

EphA2 and EGFR: Friends in Life, Partners in Crime. Can EphA2 Be a Predictive Biomarker of Response to Anti-EGFR Agents?
por: Cioce, Mario, et al.
Publicado: (2021)

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations
por: Qin, Haina, et al.
Publicado: (2012)

EphA3 Functions are Regulated by Collaborating Phosphotyrosine Residues
por: Shi, Guanfang, et al.
Publicado: (2010)

EphA4 is a prognostic factor in gastric cancer
por: Miyazaki, Kohji, et al.
Publicado: (2013)

Unliganded EphA3 dimerization promoted by the SAM domain
por: Singh, Deo R., et al.
Publicado: (2015)

Identification and characterization of Nanobodies targeting the EphA4 receptor
por: Schoonaert, Lies, et al.
Publicado: (2017)

Oncogenic Functions and Therapeutic Targeting of EphA2 in Cancer
por: Wilson, Kalin, et al.
Publicado: (2021)

EphA4 Receptor Tyrosine Kinase Is a Modulator of Onset and Disease Severity of Experimental Autoimmune Encephalomyelitis (EAE)
por: Munro, Kathryn M., et al.
Publicado: (2013)

Claudin-4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through β-catenin
por: Shang, Xiying, et al.
Publicado: (2014)

Differential Roles for EphA and EphB Signaling in Segregation and Patterning of Central Vestibulocochlear Nerve Projections
por: Allen-Sharpley, Michelle R., et al.
Publicado: (2013)

Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery
por: Stammes, Marieke A., et al.
Publicado: (2017)

EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2
por: Cui, Shuang, et al.
Publicado: (2021)

Novel [(111)In]In-BnDTPA-EphA2-230-1 Antibody for Single-Photon Emission Computed Tomography Imaging Tracer Targeting of EphA2
por: Furukawa, Takenori, et al.
Publicado: (2023)

Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer
por: Eriksson, Oskar, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3g67vq1nktpge1b76nauv77ak4