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Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule

The angiogenic process is controlled by variety of factors of which the vascular endothelial growth factor (VEGF) pathway plays a major role. A series of heparan sulfate mimetic small molecules targeting VEGF/VEGFR pathway has been synthesized. Among them, compound 8 (2-butyl-5-chloro-3-(4-nitro-ben...

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Detalles Bibliográficos
Autores principales:	Sugahara, Kazuyuki, Thimmaiah, Kuntebommanahalli N., Bid, Hemant K., Houghton, Peter J., Rangappa, Kanchugarakoppal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419744/ https://www.ncbi.nlm.nih.gov/pubmed/22916091 http://dx.doi.org/10.1371/journal.pone.0039444

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