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Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation

The embryonic gonad is the only organ that takes two mutually exclusive differentiating pathways and hence gives rise to two different adult organs: testes or ovaries. The recent application of genomic tools including microarrays, next-generation sequencing approaches, and epigenetics can significan...

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Detalles Bibliográficos
Autores principales: Piferrer, Francesc, Ribas, Laia, Díaz, Noelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419836/
https://www.ncbi.nlm.nih.gov/pubmed/22544374
http://dx.doi.org/10.1007/s10126-012-9445-4
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author Piferrer, Francesc
Ribas, Laia
Díaz, Noelia
author_facet Piferrer, Francesc
Ribas, Laia
Díaz, Noelia
author_sort Piferrer, Francesc
collection PubMed
description The embryonic gonad is the only organ that takes two mutually exclusive differentiating pathways and hence gives rise to two different adult organs: testes or ovaries. The recent application of genomic tools including microarrays, next-generation sequencing approaches, and epigenetics can significantly contribute to decipher the molecular mechanisms involved in the processes of sex determination and sex differentiation. However, in fish, these studies are complicated by the fact that these processes depend, perhaps to a larger extent when compared to other vertebrates, on the interplay of genetic and environmental influences. Here, we review the advances made so far, taking into account different experimental approaches, and illustrate some technical complications deriving from the fact that as development progresses it becomes more and more difficult to distinguish whether changes in gene expression or DNA methylation patterns are the cause or the consequence of such developmental events. Finally, we suggest some avenues for further research in both model fish species and fish species facing specific problems within an aquaculture context.
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spelling pubmed-34198362012-08-17 Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation Piferrer, Francesc Ribas, Laia Díaz, Noelia Mar Biotechnol (NY) Original Article The embryonic gonad is the only organ that takes two mutually exclusive differentiating pathways and hence gives rise to two different adult organs: testes or ovaries. The recent application of genomic tools including microarrays, next-generation sequencing approaches, and epigenetics can significantly contribute to decipher the molecular mechanisms involved in the processes of sex determination and sex differentiation. However, in fish, these studies are complicated by the fact that these processes depend, perhaps to a larger extent when compared to other vertebrates, on the interplay of genetic and environmental influences. Here, we review the advances made so far, taking into account different experimental approaches, and illustrate some technical complications deriving from the fact that as development progresses it becomes more and more difficult to distinguish whether changes in gene expression or DNA methylation patterns are the cause or the consequence of such developmental events. Finally, we suggest some avenues for further research in both model fish species and fish species facing specific problems within an aquaculture context. Springer-Verlag 2012-04-29 2012 /pmc/articles/PMC3419836/ /pubmed/22544374 http://dx.doi.org/10.1007/s10126-012-9445-4 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Piferrer, Francesc
Ribas, Laia
Díaz, Noelia
Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation
title Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation
title_full Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation
title_fullStr Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation
title_full_unstemmed Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation
title_short Genomic Approaches to Study Genetic and Environmental Influences on Fish Sex Determination and Differentiation
title_sort genomic approaches to study genetic and environmental influences on fish sex determination and differentiation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419836/
https://www.ncbi.nlm.nih.gov/pubmed/22544374
http://dx.doi.org/10.1007/s10126-012-9445-4
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