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Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing

The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of α-tropomyosin is enhanced by Raver1, a protein with four PTB-Raver1 interacting motifs (PRIs) that bind to the helical face of the second RNA recognition motif (RRM2) in PTB. W...

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Detalles Bibliográficos
Autores principales:	Joshi, Amar, Coelho, Miguel B., Kotik-Kogan, Olga, Simpson, Peter J., Matthews, Stephen J., Smith, Christopher W.J., Curry, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420021/ https://www.ncbi.nlm.nih.gov/pubmed/22153504 http://dx.doi.org/10.1016/j.str.2011.09.020

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