The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss

BACKGROUND: To date, the role of male factor contributing in evaluation of spontaneous recurrent pregnancy loss (RPL) has been less investigated and there is discrepancy in the role of Y chromosome microdeltions in RPL. Therefore, the current study was designed to examine whether Y chromosome microd...

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Autores principales: Ghorbian, S, Saliminejad, K, Sadeghi, M R, Javadi, Gh R, Kamali, K, Amirjannati, N, Bahreini, F, Edalatkhah, H, Khorram Khorshid, H R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420026/
https://www.ncbi.nlm.nih.gov/pubmed/22924114
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author Ghorbian, S
Saliminejad, K
Sadeghi, M R
Javadi, Gh R
Kamali, K
Amirjannati, N
Bahreini, F
Edalatkhah, H
Khorram Khorshid, H R
author_facet Ghorbian, S
Saliminejad, K
Sadeghi, M R
Javadi, Gh R
Kamali, K
Amirjannati, N
Bahreini, F
Edalatkhah, H
Khorram Khorshid, H R
author_sort Ghorbian, S
collection PubMed
description BACKGROUND: To date, the role of male factor contributing in evaluation of spontaneous recurrent pregnancy loss (RPL) has been less investigated and there is discrepancy in the role of Y chromosome microdeltions in RPL. Therefore, the current study was designed to examine whether Y chromosome microdeletions were associated with RPL in an Iranian population. METHODS: One hundred men from couples, experiencing three or more RPLs, and one hundred normal men from couples with at least one child and no history of miscarriages as control group were included. Genomic DNA was extracted from peripheral blood and tested for Y chromosome microdeletions in AZFa, AZFb and AZFc regions using two multiplex PCR. RESULTS: None of the men in the case and control groups had any microdeletions in the AZFa, AZFb and AZFc regions. CONCLUSION: It seems that Y chromosome microdeletion is not associated with recurrent pregnancy loss, therefore performing this test in Iranian couples with RPL is not recommended.
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spelling pubmed-34200262012-08-24 The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss Ghorbian, S Saliminejad, K Sadeghi, M R Javadi, Gh R Kamali, K Amirjannati, N Bahreini, F Edalatkhah, H Khorram Khorshid, H R Iran Red Crescent Med J Original Article BACKGROUND: To date, the role of male factor contributing in evaluation of spontaneous recurrent pregnancy loss (RPL) has been less investigated and there is discrepancy in the role of Y chromosome microdeltions in RPL. Therefore, the current study was designed to examine whether Y chromosome microdeletions were associated with RPL in an Iranian population. METHODS: One hundred men from couples, experiencing three or more RPLs, and one hundred normal men from couples with at least one child and no history of miscarriages as control group were included. Genomic DNA was extracted from peripheral blood and tested for Y chromosome microdeletions in AZFa, AZFb and AZFc regions using two multiplex PCR. RESULTS: None of the men in the case and control groups had any microdeletions in the AZFa, AZFb and AZFc regions. CONCLUSION: It seems that Y chromosome microdeletion is not associated with recurrent pregnancy loss, therefore performing this test in Iranian couples with RPL is not recommended. Kowsar 2012-06 2012-06-30 /pmc/articles/PMC3420026/ /pubmed/22924114 Text en Copyright © 2012, Kowsar Corp. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ghorbian, S
Saliminejad, K
Sadeghi, M R
Javadi, Gh R
Kamali, K
Amirjannati, N
Bahreini, F
Edalatkhah, H
Khorram Khorshid, H R
The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss
title The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss
title_full The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss
title_fullStr The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss
title_full_unstemmed The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss
title_short The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss
title_sort association between y chromosome microdeletion and recurrent pregnancy loss
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420026/
https://www.ncbi.nlm.nih.gov/pubmed/22924114
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