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Placental Mesenchymal Dysplasia: A Case Report

Introduction. A rare case of histologically proven placental mesenchymal dysplasia (PMD) with fetal omphalocele in a 22-year-old patient is reported. Material and Methods. Antenatal ultrasound of this patient showed hydropic placenta with a live fetus of 17 weeks period of gestation associated with...

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Autores principales: Agarwal, Rachna, Khatuja, Ritu, Sharma, Lipi, Singh, Alpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420089/
https://www.ncbi.nlm.nih.gov/pubmed/22919524
http://dx.doi.org/10.1155/2012/202797
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author Agarwal, Rachna
Khatuja, Ritu
Sharma, Lipi
Singh, Alpana
author_facet Agarwal, Rachna
Khatuja, Ritu
Sharma, Lipi
Singh, Alpana
author_sort Agarwal, Rachna
collection PubMed
description Introduction. A rare case of histologically proven placental mesenchymal dysplasia (PMD) with fetal omphalocele in a 22-year-old patient is reported. Material and Methods. Antenatal ultrasound of this patient showed hydropic placenta with a live fetus of 17 weeks period of gestation associated with omphalocele. Cordocentesis detected the diploid karyotype of the fetus. Patient, when prognosticated, choose to terminate the pregnancy in view of high incidence of fetal and placental anomalies. Subsequent histopathological examination of placenta established the diagnosis to be placental mesenchymal dysplasia. Conclusion. On clinical and ultrasonic grounds, suspicion of P.M.D. arises when hydropic placenta with a live fetus presents in second trimester of pregnancy. Cordocentesis can detect the diploid karyotype of the fetus in such cases. As this condition is prognostically better than triploid partial mole, continuation of pregnancy can sometimes be considered after through antenatal screening and patient counseling. However, a definite diagnosis of P.M.D. is made only on placental histology by absence of trophoblast hyperplasia and trophoblastic inclusions.
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spelling pubmed-34200892012-08-23 Placental Mesenchymal Dysplasia: A Case Report Agarwal, Rachna Khatuja, Ritu Sharma, Lipi Singh, Alpana Case Rep Obstet Gynecol Case Report Introduction. A rare case of histologically proven placental mesenchymal dysplasia (PMD) with fetal omphalocele in a 22-year-old patient is reported. Material and Methods. Antenatal ultrasound of this patient showed hydropic placenta with a live fetus of 17 weeks period of gestation associated with omphalocele. Cordocentesis detected the diploid karyotype of the fetus. Patient, when prognosticated, choose to terminate the pregnancy in view of high incidence of fetal and placental anomalies. Subsequent histopathological examination of placenta established the diagnosis to be placental mesenchymal dysplasia. Conclusion. On clinical and ultrasonic grounds, suspicion of P.M.D. arises when hydropic placenta with a live fetus presents in second trimester of pregnancy. Cordocentesis can detect the diploid karyotype of the fetus in such cases. As this condition is prognostically better than triploid partial mole, continuation of pregnancy can sometimes be considered after through antenatal screening and patient counseling. However, a definite diagnosis of P.M.D. is made only on placental histology by absence of trophoblast hyperplasia and trophoblastic inclusions. Hindawi Publishing Corporation 2012 2012-08-05 /pmc/articles/PMC3420089/ /pubmed/22919524 http://dx.doi.org/10.1155/2012/202797 Text en Copyright © 2012 Rachna Agarwal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Agarwal, Rachna
Khatuja, Ritu
Sharma, Lipi
Singh, Alpana
Placental Mesenchymal Dysplasia: A Case Report
title Placental Mesenchymal Dysplasia: A Case Report
title_full Placental Mesenchymal Dysplasia: A Case Report
title_fullStr Placental Mesenchymal Dysplasia: A Case Report
title_full_unstemmed Placental Mesenchymal Dysplasia: A Case Report
title_short Placental Mesenchymal Dysplasia: A Case Report
title_sort placental mesenchymal dysplasia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420089/
https://www.ncbi.nlm.nih.gov/pubmed/22919524
http://dx.doi.org/10.1155/2012/202797
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