The Involvement of Microglial Cells in Japanese Encephalitis Infections

Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases adm...

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Detalles Bibliográficos
Autores principales: Thongtan, Thananya, Thepparit, Chutima, Smith, Duncan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420229/
https://www.ncbi.nlm.nih.gov/pubmed/22919405
http://dx.doi.org/10.1155/2012/890586
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author Thongtan, Thananya
Thepparit, Chutima
Smith, Duncan R.
author_facet Thongtan, Thananya
Thepparit, Chutima
Smith, Duncan R.
author_sort Thongtan, Thananya
collection PubMed
description Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
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spelling pubmed-34202292012-08-23 The Involvement of Microglial Cells in Japanese Encephalitis Infections Thongtan, Thananya Thepparit, Chutima Smith, Duncan R. Clin Dev Immunol Review Article Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection. Hindawi Publishing Corporation 2012 2012-08-07 /pmc/articles/PMC3420229/ /pubmed/22919405 http://dx.doi.org/10.1155/2012/890586 Text en Copyright © 2012 Thananya Thongtan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Thongtan, Thananya
Thepparit, Chutima
Smith, Duncan R.
The Involvement of Microglial Cells in Japanese Encephalitis Infections
title The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_full The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_fullStr The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_full_unstemmed The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_short The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_sort involvement of microglial cells in japanese encephalitis infections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420229/
https://www.ncbi.nlm.nih.gov/pubmed/22919405
http://dx.doi.org/10.1155/2012/890586
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