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The Involvement of Microglial Cells in Japanese Encephalitis Infections
Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases adm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420229/ https://www.ncbi.nlm.nih.gov/pubmed/22919405 http://dx.doi.org/10.1155/2012/890586 |
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author | Thongtan, Thananya Thepparit, Chutima Smith, Duncan R. |
author_facet | Thongtan, Thananya Thepparit, Chutima Smith, Duncan R. |
author_sort | Thongtan, Thananya |
collection | PubMed |
description | Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection. |
format | Online Article Text |
id | pubmed-3420229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34202292012-08-23 The Involvement of Microglial Cells in Japanese Encephalitis Infections Thongtan, Thananya Thepparit, Chutima Smith, Duncan R. Clin Dev Immunol Review Article Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection. Hindawi Publishing Corporation 2012 2012-08-07 /pmc/articles/PMC3420229/ /pubmed/22919405 http://dx.doi.org/10.1155/2012/890586 Text en Copyright © 2012 Thananya Thongtan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Thongtan, Thananya Thepparit, Chutima Smith, Duncan R. The Involvement of Microglial Cells in Japanese Encephalitis Infections |
title | The Involvement of Microglial Cells in Japanese Encephalitis Infections |
title_full | The Involvement of Microglial Cells in Japanese Encephalitis Infections |
title_fullStr | The Involvement of Microglial Cells in Japanese Encephalitis Infections |
title_full_unstemmed | The Involvement of Microglial Cells in Japanese Encephalitis Infections |
title_short | The Involvement of Microglial Cells in Japanese Encephalitis Infections |
title_sort | involvement of microglial cells in japanese encephalitis infections |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420229/ https://www.ncbi.nlm.nih.gov/pubmed/22919405 http://dx.doi.org/10.1155/2012/890586 |
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