Myxobacteria: natural pharmaceutical factories

Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of h...

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Autores principales: Diez, Juana, Martinez, Javier P, Mestres, Jordi, Sasse, Florenz, Frank, Ronald, Meyerhans, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420326/
https://www.ncbi.nlm.nih.gov/pubmed/22545867
http://dx.doi.org/10.1186/1475-2859-11-52
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author Diez, Juana
Martinez, Javier P
Mestres, Jordi
Sasse, Florenz
Frank, Ronald
Meyerhans, Andreas
author_facet Diez, Juana
Martinez, Javier P
Mestres, Jordi
Sasse, Florenz
Frank, Ronald
Meyerhans, Andreas
author_sort Diez, Juana
collection PubMed
description Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.
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spelling pubmed-34203262012-08-17 Myxobacteria: natural pharmaceutical factories Diez, Juana Martinez, Javier P Mestres, Jordi Sasse, Florenz Frank, Ronald Meyerhans, Andreas Microb Cell Fact Commentary Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution. BioMed Central 2012-04-30 /pmc/articles/PMC3420326/ /pubmed/22545867 http://dx.doi.org/10.1186/1475-2859-11-52 Text en Copyright ©2012 Diez et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Diez, Juana
Martinez, Javier P
Mestres, Jordi
Sasse, Florenz
Frank, Ronald
Meyerhans, Andreas
Myxobacteria: natural pharmaceutical factories
title Myxobacteria: natural pharmaceutical factories
title_full Myxobacteria: natural pharmaceutical factories
title_fullStr Myxobacteria: natural pharmaceutical factories
title_full_unstemmed Myxobacteria: natural pharmaceutical factories
title_short Myxobacteria: natural pharmaceutical factories
title_sort myxobacteria: natural pharmaceutical factories
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420326/
https://www.ncbi.nlm.nih.gov/pubmed/22545867
http://dx.doi.org/10.1186/1475-2859-11-52
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