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Thymocytes may persist and differentiate without any input from bone marrow progenitors

Thymus transplants can correct deficiencies of the thymus epithelium caused by the complete DiGeorge syndrome or FOXN1 mutations. However, thymus transplants were never used to correct T cell–intrinsic deficiencies because it is generally believed that thymocytes have short intrinsic lifespans. This...

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Detalles Bibliográficos
Autores principales:	Peaudecerf, Laetitia, Lemos, Sara, Galgano, Alessia, Krenn, Gerald, Vasseur, Florence, Di Santo, James P., Ezine, Sophie, Rocha, Benedita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420331/ https://www.ncbi.nlm.nih.gov/pubmed/22778388 http://dx.doi.org/10.1084/jem.20120845

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