Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia

We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with tolui...

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Autores principales: Rojas-Atencio, Alicia, Urdaneta, Karelis, Soto-Quintana, Marisol, Alvarez Nava, Francisco, Cañizales, Jenny, Solis, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420414/
https://www.ncbi.nlm.nih.gov/pubmed/22937382
http://dx.doi.org/10.1155/2011/269491
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author Rojas-Atencio, Alicia
Urdaneta, Karelis
Soto-Quintana, Marisol
Alvarez Nava, Francisco
Cañizales, Jenny
Solis, Ernesto
author_facet Rojas-Atencio, Alicia
Urdaneta, Karelis
Soto-Quintana, Marisol
Alvarez Nava, Francisco
Cañizales, Jenny
Solis, Ernesto
author_sort Rojas-Atencio, Alicia
collection PubMed
description We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22).
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spelling pubmed-34204142012-08-30 Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia Rojas-Atencio, Alicia Urdaneta, Karelis Soto-Quintana, Marisol Alvarez Nava, Francisco Cañizales, Jenny Solis, Ernesto Case Rep Pathol Case Report We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22). Hindawi Publishing Corporation 2011 2011-09-13 /pmc/articles/PMC3420414/ /pubmed/22937382 http://dx.doi.org/10.1155/2011/269491 Text en Copyright © 2011 Alicia Rojas-Atencio et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rojas-Atencio, Alicia
Urdaneta, Karelis
Soto-Quintana, Marisol
Alvarez Nava, Francisco
Cañizales, Jenny
Solis, Ernesto
Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_full Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_fullStr Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_full_unstemmed Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_short Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
title_sort trisomy 19 and t(9;22) in a patient with acute basophilic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420414/
https://www.ncbi.nlm.nih.gov/pubmed/22937382
http://dx.doi.org/10.1155/2011/269491
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