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High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by c...

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Autores principales: Momeni, Naghi, Brudin, Lars, Behnia, Fatemeh, Nordström, Berit, Yosefi-Oudarji, Ali, Sivberg, Bengt, Joghataei, Mohammad T., Persson, Bengt L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420436/
https://www.ncbi.nlm.nih.gov/pubmed/22928102
http://dx.doi.org/10.1155/2012/868576
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author Momeni, Naghi
Brudin, Lars
Behnia, Fatemeh
Nordström, Berit
Yosefi-Oudarji, Ali
Sivberg, Bengt
Joghataei, Mohammad T.
Persson, Bengt L.
author_facet Momeni, Naghi
Brudin, Lars
Behnia, Fatemeh
Nordström, Berit
Yosefi-Oudarji, Ali
Sivberg, Bengt
Joghataei, Mohammad T.
Persson, Bengt L.
author_sort Momeni, Naghi
collection PubMed
description Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD.
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spelling pubmed-34204362012-08-27 High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders Momeni, Naghi Brudin, Lars Behnia, Fatemeh Nordström, Berit Yosefi-Oudarji, Ali Sivberg, Bengt Joghataei, Mohammad T. Persson, Bengt L. Autism Res Treat Clinical Study Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD. Hindawi Publishing Corporation 2012 2011-10-24 /pmc/articles/PMC3420436/ /pubmed/22928102 http://dx.doi.org/10.1155/2012/868576 Text en Copyright © 2012 Naghi Momeni et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Momeni, Naghi
Brudin, Lars
Behnia, Fatemeh
Nordström, Berit
Yosefi-Oudarji, Ali
Sivberg, Bengt
Joghataei, Mohammad T.
Persson, Bengt L.
High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
title High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
title_full High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
title_fullStr High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
title_full_unstemmed High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
title_short High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
title_sort high complement factor i activity in the plasma of children with autism spectrum disorders
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420436/
https://www.ncbi.nlm.nih.gov/pubmed/22928102
http://dx.doi.org/10.1155/2012/868576
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