Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases

Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metasta...

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Autores principales: Rowland, Nathan C., Andrews, Jennifer, Patel, Daxa, LaBorde, David V., Nowlan, Adam, George, Bradley, Mazewski, Claire, Reisner, Andrew, Katzenstein, Howard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420513/
https://www.ncbi.nlm.nih.gov/pubmed/22937356
http://dx.doi.org/10.1155/2012/690548
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author Rowland, Nathan C.
Andrews, Jennifer
Patel, Daxa
LaBorde, David V.
Nowlan, Adam
George, Bradley
Mazewski, Claire
Reisner, Andrew
Katzenstein, Howard M.
author_facet Rowland, Nathan C.
Andrews, Jennifer
Patel, Daxa
LaBorde, David V.
Nowlan, Adam
George, Bradley
Mazewski, Claire
Reisner, Andrew
Katzenstein, Howard M.
author_sort Rowland, Nathan C.
collection PubMed
description Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.
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spelling pubmed-34205132012-08-30 Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases Rowland, Nathan C. Andrews, Jennifer Patel, Daxa LaBorde, David V. Nowlan, Adam George, Bradley Mazewski, Claire Reisner, Andrew Katzenstein, Howard M. Case Rep Neurol Med Case Report Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease. Hindawi Publishing Corporation 2012 2012-01-19 /pmc/articles/PMC3420513/ /pubmed/22937356 http://dx.doi.org/10.1155/2012/690548 Text en Copyright © 2012 Nathan C. Rowland et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rowland, Nathan C.
Andrews, Jennifer
Patel, Daxa
LaBorde, David V.
Nowlan, Adam
George, Bradley
Mazewski, Claire
Reisner, Andrew
Katzenstein, Howard M.
Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
title Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
title_full Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
title_fullStr Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
title_full_unstemmed Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
title_short Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
title_sort intracranial metastatic neuroblastoma treated with gamma knife stereotactic radiosurgery: report of two novel cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420513/
https://www.ncbi.nlm.nih.gov/pubmed/22937356
http://dx.doi.org/10.1155/2012/690548
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