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Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature

Case histories of a mother and her two children are reported. The mother was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently abnormal erythrocyte transketolase studies indicating abnor...

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Detalles Bibliográficos
Autores principales: Lonsdale, Derrick, Shamberger, Raymond J., Obrenovich, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420600/
https://www.ncbi.nlm.nih.gov/pubmed/22937241
http://dx.doi.org/10.1155/2011/129795
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author Lonsdale, Derrick
Shamberger, Raymond J.
Obrenovich, Mark E.
author_facet Lonsdale, Derrick
Shamberger, Raymond J.
Obrenovich, Mark E.
author_sort Lonsdale, Derrick
collection PubMed
description Case histories of a mother and her two children are reported. The mother was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently abnormal erythrocyte transketolase studies indicating abnormal thiamine pyrophosphate homeostasis. Both children had unusual concentrations of urinary arsenic. All had symptomatic improvement with diet restriction and supplementary vitamin therapy but quickly relapsed after ingestion of sugar, milk, or wheat. The stress of a heavy metal burden, superimposed on existing genetic or epigenetic risk factors, may be important in the etiology of autism spectrum disorder when in combination. Dysautonomia has been associated with several diseases, including autism, without a common etiology. It is hypothesized that oxidative stress results in loss of cellular energy and causes retardation of hard wiring of the brain in infancy, affecting limbic system control of the autonomic nervous system.
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spelling pubmed-34206002012-08-30 Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature Lonsdale, Derrick Shamberger, Raymond J. Obrenovich, Mark E. Autism Res Treat Review Article Case histories of a mother and her two children are reported. The mother was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently abnormal erythrocyte transketolase studies indicating abnormal thiamine pyrophosphate homeostasis. Both children had unusual concentrations of urinary arsenic. All had symptomatic improvement with diet restriction and supplementary vitamin therapy but quickly relapsed after ingestion of sugar, milk, or wheat. The stress of a heavy metal burden, superimposed on existing genetic or epigenetic risk factors, may be important in the etiology of autism spectrum disorder when in combination. Dysautonomia has been associated with several diseases, including autism, without a common etiology. It is hypothesized that oxidative stress results in loss of cellular energy and causes retardation of hard wiring of the brain in infancy, affecting limbic system control of the autonomic nervous system. Hindawi Publishing Corporation 2011 2011-05-31 /pmc/articles/PMC3420600/ /pubmed/22937241 http://dx.doi.org/10.1155/2011/129795 Text en Copyright © 2011 Derrick Lonsdale et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lonsdale, Derrick
Shamberger, Raymond J.
Obrenovich, Mark E.
Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
title Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
title_full Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
title_fullStr Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
title_full_unstemmed Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
title_short Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
title_sort dysautonomia in autism spectrum disorder: case reports of a family with review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420600/
https://www.ncbi.nlm.nih.gov/pubmed/22937241
http://dx.doi.org/10.1155/2011/129795
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