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Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature
Case histories of a mother and her two children are reported. The mother was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently abnormal erythrocyte transketolase studies indicating abnor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420600/ https://www.ncbi.nlm.nih.gov/pubmed/22937241 http://dx.doi.org/10.1155/2011/129795 |
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author | Lonsdale, Derrick Shamberger, Raymond J. Obrenovich, Mark E. |
author_facet | Lonsdale, Derrick Shamberger, Raymond J. Obrenovich, Mark E. |
author_sort | Lonsdale, Derrick |
collection | PubMed |
description | Case histories of a mother and her two children are reported. The mother was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently abnormal erythrocyte transketolase studies indicating abnormal thiamine pyrophosphate homeostasis. Both children had unusual concentrations of urinary arsenic. All had symptomatic improvement with diet restriction and supplementary vitamin therapy but quickly relapsed after ingestion of sugar, milk, or wheat. The stress of a heavy metal burden, superimposed on existing genetic or epigenetic risk factors, may be important in the etiology of autism spectrum disorder when in combination. Dysautonomia has been associated with several diseases, including autism, without a common etiology. It is hypothesized that oxidative stress results in loss of cellular energy and causes retardation of hard wiring of the brain in infancy, affecting limbic system control of the autonomic nervous system. |
format | Online Article Text |
id | pubmed-3420600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34206002012-08-30 Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature Lonsdale, Derrick Shamberger, Raymond J. Obrenovich, Mark E. Autism Res Treat Review Article Case histories of a mother and her two children are reported. The mother was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently abnormal erythrocyte transketolase studies indicating abnormal thiamine pyrophosphate homeostasis. Both children had unusual concentrations of urinary arsenic. All had symptomatic improvement with diet restriction and supplementary vitamin therapy but quickly relapsed after ingestion of sugar, milk, or wheat. The stress of a heavy metal burden, superimposed on existing genetic or epigenetic risk factors, may be important in the etiology of autism spectrum disorder when in combination. Dysautonomia has been associated with several diseases, including autism, without a common etiology. It is hypothesized that oxidative stress results in loss of cellular energy and causes retardation of hard wiring of the brain in infancy, affecting limbic system control of the autonomic nervous system. Hindawi Publishing Corporation 2011 2011-05-31 /pmc/articles/PMC3420600/ /pubmed/22937241 http://dx.doi.org/10.1155/2011/129795 Text en Copyright © 2011 Derrick Lonsdale et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lonsdale, Derrick Shamberger, Raymond J. Obrenovich, Mark E. Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature |
title | Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature |
title_full | Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature |
title_fullStr | Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature |
title_full_unstemmed | Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature |
title_short | Dysautonomia in Autism Spectrum Disorder: Case Reports of a Family with Review of the Literature |
title_sort | dysautonomia in autism spectrum disorder: case reports of a family with review of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420600/ https://www.ncbi.nlm.nih.gov/pubmed/22937241 http://dx.doi.org/10.1155/2011/129795 |
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