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Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report
One male with unilateral osteoarthritis (OA) of the knee underwent testing of corticospinal (CS) excitability (as quantified from motor-evoked potentials (MEPs) in the rectus femoris (RF) using transcranial magnetic stimulation) and quadriceps muscle strength. Baseline data indicated reduced MEP amp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420629/ https://www.ncbi.nlm.nih.gov/pubmed/22937446 http://dx.doi.org/10.1155/2011/537420 |
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author | Hunt, Michael A. Zabukovec, Jeanie R. Peters, Sue Pollock, Courtney L. Linsdell, Meghan A. Boyd, Lara A. |
author_facet | Hunt, Michael A. Zabukovec, Jeanie R. Peters, Sue Pollock, Courtney L. Linsdell, Meghan A. Boyd, Lara A. |
author_sort | Hunt, Michael A. |
collection | PubMed |
description | One male with unilateral osteoarthritis (OA) of the knee underwent testing of corticospinal (CS) excitability (as quantified from motor-evoked potentials (MEPs) in the rectus femoris (RF) using transcranial magnetic stimulation) and quadriceps muscle strength. Baseline data indicated reduced MEP amplitudes in the RF of the affected limb compared to the unaffected limb. Increases in RF MEP amplitudes from both limbs were observed immediately following a 30-minute exercise session focusing on muscle strengthening. Following an 8-week muscle strengthening intervention, the participant exhibited increased MEP amplitudes and muscle strength in the affected limb. These findings suggest that alterations in peripheral muscle function found in patients with knee OA may have an origin centrally within the motor cortex and that interlimb differences may be evident in those with unilateral disease. These findings also suggest that CS excitability may be improved following a muscle strengthening intervention. |
format | Online Article Text |
id | pubmed-3420629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34206292012-08-30 Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report Hunt, Michael A. Zabukovec, Jeanie R. Peters, Sue Pollock, Courtney L. Linsdell, Meghan A. Boyd, Lara A. Case Rep Rheumatol Case Report One male with unilateral osteoarthritis (OA) of the knee underwent testing of corticospinal (CS) excitability (as quantified from motor-evoked potentials (MEPs) in the rectus femoris (RF) using transcranial magnetic stimulation) and quadriceps muscle strength. Baseline data indicated reduced MEP amplitudes in the RF of the affected limb compared to the unaffected limb. Increases in RF MEP amplitudes from both limbs were observed immediately following a 30-minute exercise session focusing on muscle strengthening. Following an 8-week muscle strengthening intervention, the participant exhibited increased MEP amplitudes and muscle strength in the affected limb. These findings suggest that alterations in peripheral muscle function found in patients with knee OA may have an origin centrally within the motor cortex and that interlimb differences may be evident in those with unilateral disease. These findings also suggest that CS excitability may be improved following a muscle strengthening intervention. Hindawi Publishing Corporation 2011 2011-09-29 /pmc/articles/PMC3420629/ /pubmed/22937446 http://dx.doi.org/10.1155/2011/537420 Text en Copyright © 2011 Michael A. Hunt et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Hunt, Michael A. Zabukovec, Jeanie R. Peters, Sue Pollock, Courtney L. Linsdell, Meghan A. Boyd, Lara A. Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report |
title | Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report |
title_full | Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report |
title_fullStr | Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report |
title_full_unstemmed | Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report |
title_short | Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report |
title_sort | reduced quadriceps motor-evoked potentials in an individual with unilateral knee osteoarthritis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420629/ https://www.ncbi.nlm.nih.gov/pubmed/22937446 http://dx.doi.org/10.1155/2011/537420 |
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