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Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the U.S., yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF)...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420731/ https://www.ncbi.nlm.nih.gov/pubmed/22937258 http://dx.doi.org/10.1155/2012/205362 |
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author | Onore, Charity Van de Water, Judy Ashwood, Paul |
author_facet | Onore, Charity Van de Water, Judy Ashwood, Paul |
author_sort | Onore, Charity |
collection | PubMed |
description | Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the U.S., yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P = 0.003). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. |
format | Online Article Text |
id | pubmed-3420731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34207312012-08-30 Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder Onore, Charity Van de Water, Judy Ashwood, Paul Autism Res Treat Research Article Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the U.S., yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P = 0.003). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. Hindawi Publishing Corporation 2012 2012-03-05 /pmc/articles/PMC3420731/ /pubmed/22937258 http://dx.doi.org/10.1155/2012/205362 Text en Copyright © 2012 Charity Onore et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Onore, Charity Van de Water, Judy Ashwood, Paul Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder |
title | Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder |
title_full | Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder |
title_fullStr | Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder |
title_full_unstemmed | Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder |
title_short | Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder |
title_sort | decreased levels of egf in plasma of children with autism spectrum disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420731/ https://www.ncbi.nlm.nih.gov/pubmed/22937258 http://dx.doi.org/10.1155/2012/205362 |
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