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Random Mutagenesis Reveals Residues of JAK2 Critical in Evading Inhibition by a Tyrosine Kinase Inhibitor

BACKGROUND: The non-receptor tyrosine kinase JAK2 is implicated in a group of myeloproliferative neoplasms including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. JAK2-selective inhibitors are currently being evaluated in clinical trials. Data from drug-resistant chronic m...

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Detalles Bibliográficos
Autores principales:	Marit, Michael R., Chohan, Manprit, Matthew, Natasha, Huang, Kai, Kuntz, Douglas A., Rose, David R., Barber, Dwayne L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420867/ https://www.ncbi.nlm.nih.gov/pubmed/22916261 http://dx.doi.org/10.1371/journal.pone.0043437

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