Mutation Discovery in Regions of Segmental Cancer Genome Amplifications with CoNAn-SNV: A Mixture Model for Next Generation Sequencing of Tumors

Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome—in particular single nucleotide variants (SNVs). Most current computational and statistical models for analyzing next generation sequencing data, however, do not account for ca...

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Detalles Bibliográficos
Autores principales: Crisan, Anamaria, Goya, Rodrigo, Ha, Gavin, Ding, Jiarui, Prentice, Leah M., Oloumi, Arusha, Senz, Janine, Zeng, Thomas, Tse, Kane, Delaney, Allen, Marra, Marco A., Huntsman, David G., Hirst, Martin, Aparicio, Sam, Shah, Sohrab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420914/
https://www.ncbi.nlm.nih.gov/pubmed/22916110
http://dx.doi.org/10.1371/journal.pone.0041551

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