PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA

Incidence of kidney cancer is on the rise, and a better understanding of molecular mechanisms involved in the cancer invasion and metastasis is required for the development of curative therapeutics. In this study, we report that the proinflammatory cytokine prostaglandin E2 (PGE2) induces the malign...

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Detalles Bibliográficos
Autores principales: Li, Zhenyu, Zhang, Yushan, Kim, Wanju, Daaka, Yehia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421051/
https://www.ncbi.nlm.nih.gov/pubmed/22580611
http://dx.doi.org/10.1038/onc.2012.161
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author Li, Zhenyu
Zhang, Yushan
Kim, Wanju
Daaka, Yehia
author_facet Li, Zhenyu
Zhang, Yushan
Kim, Wanju
Daaka, Yehia
author_sort Li, Zhenyu
collection PubMed
description Incidence of kidney cancer is on the rise, and a better understanding of molecular mechanisms involved in the cancer invasion and metastasis is required for the development of curative therapeutics. In this study, we report that the proinflammatory cytokine prostaglandin E2 (PGE2) induces the malignant SN12C, but not benign HK2 kidney cell invasion. The PGE2 increases SN12C cell invasion through a signal pathway that encompasses EP2 and EP4, Akt, small GTPase RalA and Ral GTP inactivator RGC2. The results support the idea that targeted interference of EP2/EP4 signal to RalA GTP may provide benefit to patients diagnosed with advanced kidney cancer.
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spelling pubmed-34210512013-09-14 PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA Li, Zhenyu Zhang, Yushan Kim, Wanju Daaka, Yehia Oncogene Article Incidence of kidney cancer is on the rise, and a better understanding of molecular mechanisms involved in the cancer invasion and metastasis is required for the development of curative therapeutics. In this study, we report that the proinflammatory cytokine prostaglandin E2 (PGE2) induces the malignant SN12C, but not benign HK2 kidney cell invasion. The PGE2 increases SN12C cell invasion through a signal pathway that encompasses EP2 and EP4, Akt, small GTPase RalA and Ral GTP inactivator RGC2. The results support the idea that targeted interference of EP2/EP4 signal to RalA GTP may provide benefit to patients diagnosed with advanced kidney cancer. 2012-05-14 2013-03-14 /pmc/articles/PMC3421051/ /pubmed/22580611 http://dx.doi.org/10.1038/onc.2012.161 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Li, Zhenyu
Zhang, Yushan
Kim, Wanju
Daaka, Yehia
PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA
title PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA
title_full PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA
title_fullStr PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA
title_full_unstemmed PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA
title_short PGE2 Promotes Renal Carcinoma Cell Invasion through Activated RalA
title_sort pge2 promotes renal carcinoma cell invasion through activated rala
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421051/
https://www.ncbi.nlm.nih.gov/pubmed/22580611
http://dx.doi.org/10.1038/onc.2012.161
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AT zhangyushan pge2promotesrenalcarcinomacellinvasionthroughactivatedrala
AT kimwanju pge2promotesrenalcarcinomacellinvasionthroughactivatedrala
AT daakayehia pge2promotesrenalcarcinomacellinvasionthroughactivatedrala

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