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Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants

This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term...

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Autor principal: Littrell, Jill Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421432/
https://www.ncbi.nlm.nih.gov/pubmed/22912626
http://dx.doi.org/10.3389/fpsyg.2012.00297
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author Littrell, Jill Leslie
author_facet Littrell, Jill Leslie
author_sort Littrell, Jill Leslie
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description This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term efficacy of antidepressants, which have short term anti-inflammatory effects. Evidence for those anti-inflammatory effects is discussed. Evidence of the contrary long-term effects of antidepressants, which increase rather than decrease inflammation, is also reviewed. It is argued that this increase in inflammation would predict an increase in chronicity among depressed patients that have been treated with antidepressants drugs, which has been noted in the literature. A brief discussion of alternatives for decreasing inflammation, some of which have demonstrated efficacy in ameliorating depression, is presented.
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spelling pubmed-34214322012-08-21 Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants Littrell, Jill Leslie Front Psychol Psychology This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term efficacy of antidepressants, which have short term anti-inflammatory effects. Evidence for those anti-inflammatory effects is discussed. Evidence of the contrary long-term effects of antidepressants, which increase rather than decrease inflammation, is also reviewed. It is argued that this increase in inflammation would predict an increase in chronicity among depressed patients that have been treated with antidepressants drugs, which has been noted in the literature. A brief discussion of alternatives for decreasing inflammation, some of which have demonstrated efficacy in ameliorating depression, is presented. Frontiers Research Foundation 2012-08-17 /pmc/articles/PMC3421432/ /pubmed/22912626 http://dx.doi.org/10.3389/fpsyg.2012.00297 Text en Copyright © 2012 Littrell. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Psychology
Littrell, Jill Leslie
Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
title Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
title_full Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
title_fullStr Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
title_full_unstemmed Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
title_short Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
title_sort taking the perspective that a depressive state reflects inflammation: implications for the use of antidepressants
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421432/
https://www.ncbi.nlm.nih.gov/pubmed/22912626
http://dx.doi.org/10.3389/fpsyg.2012.00297
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