Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS

RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood. Here, we used a reverse-engineering approach in an ovarian cancer model to reconstruct KRAS oncogene-dependent cytopla...

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Detalles Bibliográficos
Autores principales: Stelniec-Klotz, Iwona, Legewie, Stefan, Tchernitsa, Oleg, Witzel, Franziska, Klinger, Bertram, Sers, Christine, Herzel, Hanspeter, Blüthgen, Nils, Schäfer, Reinhold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421447/
https://www.ncbi.nlm.nih.gov/pubmed/22864383
http://dx.doi.org/10.1038/msb.2012.32

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