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Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD

BACKGROUND: It is widely recognized that chronic obstructive pulmonary disease (COPD) includes a variety of extra pulmonary complications and comorbidities. Recently, adiponectin was shown to regulate cellular metabolism in humans. Cellular hydration state is affected by a variety of hormonal factor...

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Autores principales: Yoshikawa, Takahiro, Kanazawa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422121/
https://www.ncbi.nlm.nih.gov/pubmed/22927754
http://dx.doi.org/10.2147/COPD.S34556
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author Yoshikawa, Takahiro
Kanazawa, Hiroshi
author_facet Yoshikawa, Takahiro
Kanazawa, Hiroshi
author_sort Yoshikawa, Takahiro
collection PubMed
description BACKGROUND: It is widely recognized that chronic obstructive pulmonary disease (COPD) includes a variety of extra pulmonary complications and comorbidities. Recently, adiponectin was shown to regulate cellular metabolism in humans. Cellular hydration state is affected by a variety of hormonal factors and regulates cellular metabolic state. Therefore, this study was designed to determine whether adiponectin is a possible factor involved in cellular hydration state in COPD. METHODS: Thirty patients with COPD and 41 age-matched controls participated in the study. Plasma levels of total and high molecular weight (HMW) adiponectin were measured and anthropometry and pulmonary function tests were conducted. Intracellular water (ICW), extracellular water (ECW), and ECW/ICW ratio, which are parameters of cellular hydration state, were measured using bioelectrical impedance analysis. RESULTS: Higher levels of total and HMW adiponectin in plasma were found in patients with COPD compared with levels in controls. A significant inverse correlation was observed between body mass index and plasma levels of total and HMW adiponectin in the control group. However, this significant correlation was not observed in patients with COPD. The plasma levels of total and HMW adiponectin were also not significantly correlated with any pulmonary function parameters in patients with COPD. Regarding the state of cellular hydration, the plasma levels of total adiponectin were inversely correlated with the ECW/ICW ratio and positively with ICW values in patients with COPD. Moreover, closer correlations were found between these parameters and plasma HMW adiponectin levels. CONCLUSION: The results of the present study suggest a novel association of the plasma adiponectin with cellular hydration state in patients with COPD. Accordingly, lower adiponectin levels may result in cellular shrinkage, leading to metabolic malfunction at a cellular level. Thus, our findings provide new insights regarding the preventive roles of adiponectin in the progression of comorbidities in COPD.
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spelling pubmed-34221212012-08-27 Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD Yoshikawa, Takahiro Kanazawa, Hiroshi Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: It is widely recognized that chronic obstructive pulmonary disease (COPD) includes a variety of extra pulmonary complications and comorbidities. Recently, adiponectin was shown to regulate cellular metabolism in humans. Cellular hydration state is affected by a variety of hormonal factors and regulates cellular metabolic state. Therefore, this study was designed to determine whether adiponectin is a possible factor involved in cellular hydration state in COPD. METHODS: Thirty patients with COPD and 41 age-matched controls participated in the study. Plasma levels of total and high molecular weight (HMW) adiponectin were measured and anthropometry and pulmonary function tests were conducted. Intracellular water (ICW), extracellular water (ECW), and ECW/ICW ratio, which are parameters of cellular hydration state, were measured using bioelectrical impedance analysis. RESULTS: Higher levels of total and HMW adiponectin in plasma were found in patients with COPD compared with levels in controls. A significant inverse correlation was observed between body mass index and plasma levels of total and HMW adiponectin in the control group. However, this significant correlation was not observed in patients with COPD. The plasma levels of total and HMW adiponectin were also not significantly correlated with any pulmonary function parameters in patients with COPD. Regarding the state of cellular hydration, the plasma levels of total adiponectin were inversely correlated with the ECW/ICW ratio and positively with ICW values in patients with COPD. Moreover, closer correlations were found between these parameters and plasma HMW adiponectin levels. CONCLUSION: The results of the present study suggest a novel association of the plasma adiponectin with cellular hydration state in patients with COPD. Accordingly, lower adiponectin levels may result in cellular shrinkage, leading to metabolic malfunction at a cellular level. Thus, our findings provide new insights regarding the preventive roles of adiponectin in the progression of comorbidities in COPD. Dove Medical Press 2012 2012-08-10 /pmc/articles/PMC3422121/ /pubmed/22927754 http://dx.doi.org/10.2147/COPD.S34556 Text en © 2012 Yoshikawa and Kanazawa, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Yoshikawa, Takahiro
Kanazawa, Hiroshi
Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD
title Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD
title_full Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD
title_fullStr Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD
title_full_unstemmed Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD
title_short Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD
title_sort association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with copd
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422121/
https://www.ncbi.nlm.nih.gov/pubmed/22927754
http://dx.doi.org/10.2147/COPD.S34556
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