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A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development
BACKGROUND: Epidemiological studies have suggested that the encounter with commensal microorganisms during the neonatal period is essential for normal development of the host immune system. Basic research involving gnotobiotic mice has demonstrated that colonization at the age of 5 weeks is too late...
Autores principales: | Yamamoto, Masahiro, Yamaguchi, Rui, Munakata, Kaori, Takashima, Kiyoe, Nishiyama, Mitsue, Hioki, Kyoji, Ohnishi, Yasuyuki, Nagasaki, Masao, Imoto, Seiya, Miyano, Satoru, Ishige, Atsushi, Watanabe, Kenji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422195/ https://www.ncbi.nlm.nih.gov/pubmed/22823934 http://dx.doi.org/10.1186/1471-2164-13-335 |
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