Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines

Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot...

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Autores principales: Wei, Kai, Sun, Zhenhong, Zhu, Shufen, Guo, Wenlong, Sheng, Pengcheng, Wang, Zunmin, Zhao, Changliang, Zhao, Qingyou, Zhu, Ruiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422243/
https://www.ncbi.nlm.nih.gov/pubmed/22912872
http://dx.doi.org/10.1371/journal.pone.0043422
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author Wei, Kai
Sun, Zhenhong
Zhu, Shufen
Guo, Wenlong
Sheng, Pengcheng
Wang, Zunmin
Zhao, Changliang
Zhao, Qingyou
Zhu, Ruiliang
author_facet Wei, Kai
Sun, Zhenhong
Zhu, Shufen
Guo, Wenlong
Sheng, Pengcheng
Wang, Zunmin
Zhao, Changliang
Zhao, Qingyou
Zhu, Ruiliang
author_sort Wei, Kai
collection PubMed
description Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines. Furthermore, the REV was probably transmitted to the commercial chickens through congenital transmission.
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spelling pubmed-34222432012-08-21 Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines Wei, Kai Sun, Zhenhong Zhu, Shufen Guo, Wenlong Sheng, Pengcheng Wang, Zunmin Zhao, Changliang Zhao, Qingyou Zhu, Ruiliang PLoS One Research Article Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines. Furthermore, the REV was probably transmitted to the commercial chickens through congenital transmission. Public Library of Science 2012-08-17 /pmc/articles/PMC3422243/ /pubmed/22912872 http://dx.doi.org/10.1371/journal.pone.0043422 Text en © 2012 Wei et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wei, Kai
Sun, Zhenhong
Zhu, Shufen
Guo, Wenlong
Sheng, Pengcheng
Wang, Zunmin
Zhao, Changliang
Zhao, Qingyou
Zhu, Ruiliang
Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines
title Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines
title_full Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines
title_fullStr Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines
title_full_unstemmed Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines
title_short Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines
title_sort probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422243/
https://www.ncbi.nlm.nih.gov/pubmed/22912872
http://dx.doi.org/10.1371/journal.pone.0043422
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