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Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma

BACKGROUND: BRAF(V600) inhibitors have offered a new gateway for better treatment of metastatic melanoma. However, the overall efficacy of BRAF(V600) inhibitors has been lower than expected in clinical trials, and many patients have shown resistance to the drug’s effect. We hypothesized that somatic...

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Detalles Bibliográficos
Autores principales:	Shull, Austin Y., Latham-Schwark, Alicia, Ramasamy, Poornema, Leskoske, Kristin, Oroian, Dora, Birtwistle, Marc R., Buckhaults, Phillip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422312/ https://www.ncbi.nlm.nih.gov/pubmed/22912864 http://dx.doi.org/10.1371/journal.pone.0043369

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