APJ ACTS AS A DUAL RECEPTOR IN CARDIAC HYPERTROPHY

Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues(1). Here we report that genetic loss of APJ confers resistance to chronic pressure overload by dramatically reducing myocardial hypertrophy and heart failure. In contr...

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Detalles Bibliográficos
Autores principales: Scimia, Maria Cecilia, Hurtado, Cecilia, Ray, Saugata, Metzler, Scott, Wei, Ke, Wang, Jianming, Woods, Chris E., Purcell, Nicole H., Catalucci, Daniele, Akasaka, Takashi, Bueno, Orlando F., Vlasuk, George P., Kaliman, Perla, Bodmer, Rolf, Smith, Layton H., Ashley, Euan, Mercola, Mark, Brown, Joan Heller, Ruiz-Lozano, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422434/
https://www.ncbi.nlm.nih.gov/pubmed/22810587
http://dx.doi.org/10.1038/nature11263

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