Cargando…
Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
BACKGROUND: In perfusion magnetic resonance imaging a manual approach to delineation of regions of interest is, due to rater bias and time intensive operator input, clinically less favorable than an automated approach would be. The goal of our study was to compare the performances of these approache...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423015/ https://www.ncbi.nlm.nih.gov/pubmed/22809148 http://dx.doi.org/10.1186/1471-2342-12-16 |
_version_ | 1782241074231640064 |
---|---|
author | Galinovic, Ivana Ostwaldt, Ann-Christin Soemmer, Carina Bros, Helena Hotter, Benjamin Brunecker, Peter Fiebach, Jochen B |
author_facet | Galinovic, Ivana Ostwaldt, Ann-Christin Soemmer, Carina Bros, Helena Hotter, Benjamin Brunecker, Peter Fiebach, Jochen B |
author_sort | Galinovic, Ivana |
collection | PubMed |
description | BACKGROUND: In perfusion magnetic resonance imaging a manual approach to delineation of regions of interest is, due to rater bias and time intensive operator input, clinically less favorable than an automated approach would be. The goal of our study was to compare the performances of these approaches. METHODS: Using Stroketool, PMA and Perfscape/Neuroscape perfusion maps of cerebral blood flow, mean transit time and Tmax were created for 145 patients with acute ischemic stroke. Volumes of hypoperfused tissue were calculated using both a manual and an automated protocol, and the results compared between methods. RESULTS: The median difference between the automatically and manually derived volumes was up to 210 ml in Perfscape/Neuroscape, 123 ml in PMA and 135 ml in Stroketool. Correlation coefficients between perfusion volumes and radiological and clinical outcome were much lower for the automatic volumes than for the manually derived ones. CONCLUSIONS: The agreement of the two methods was very poor, with the automated use producing falsely exaggerated volumes of hypoperfused tissue. Software improvements are necessary to enable highly automated protocols to credibly assess perfusion deficits. |
format | Online Article Text |
id | pubmed-3423015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34230152012-08-21 Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software Galinovic, Ivana Ostwaldt, Ann-Christin Soemmer, Carina Bros, Helena Hotter, Benjamin Brunecker, Peter Fiebach, Jochen B BMC Med Imaging Research Article BACKGROUND: In perfusion magnetic resonance imaging a manual approach to delineation of regions of interest is, due to rater bias and time intensive operator input, clinically less favorable than an automated approach would be. The goal of our study was to compare the performances of these approaches. METHODS: Using Stroketool, PMA and Perfscape/Neuroscape perfusion maps of cerebral blood flow, mean transit time and Tmax were created for 145 patients with acute ischemic stroke. Volumes of hypoperfused tissue were calculated using both a manual and an automated protocol, and the results compared between methods. RESULTS: The median difference between the automatically and manually derived volumes was up to 210 ml in Perfscape/Neuroscape, 123 ml in PMA and 135 ml in Stroketool. Correlation coefficients between perfusion volumes and radiological and clinical outcome were much lower for the automatic volumes than for the manually derived ones. CONCLUSIONS: The agreement of the two methods was very poor, with the automated use producing falsely exaggerated volumes of hypoperfused tissue. Software improvements are necessary to enable highly automated protocols to credibly assess perfusion deficits. BioMed Central 2012-07-18 /pmc/articles/PMC3423015/ /pubmed/22809148 http://dx.doi.org/10.1186/1471-2342-12-16 Text en Copyright ©2012 Galinovic et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Galinovic, Ivana Ostwaldt, Ann-Christin Soemmer, Carina Bros, Helena Hotter, Benjamin Brunecker, Peter Fiebach, Jochen B Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software |
title | Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software |
title_full | Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software |
title_fullStr | Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software |
title_full_unstemmed | Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software |
title_short | Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software |
title_sort | automated vs manual delineations of regions of interest- a comparison in commercially available perfusion mri software |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423015/ https://www.ncbi.nlm.nih.gov/pubmed/22809148 http://dx.doi.org/10.1186/1471-2342-12-16 |
work_keys_str_mv | AT galinovicivana automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware AT ostwaldtannchristin automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware AT soemmercarina automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware AT broshelena automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware AT hotterbenjamin automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware AT bruneckerpeter automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware AT fiebachjochenb automatedvsmanualdelineationsofregionsofinterestacomparisonincommerciallyavailableperfusionmrisoftware |