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Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software

BACKGROUND: In perfusion magnetic resonance imaging a manual approach to delineation of regions of interest is, due to rater bias and time intensive operator input, clinically less favorable than an automated approach would be. The goal of our study was to compare the performances of these approache...

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Autores principales: Galinovic, Ivana, Ostwaldt, Ann-Christin, Soemmer, Carina, Bros, Helena, Hotter, Benjamin, Brunecker, Peter, Fiebach, Jochen B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423015/
https://www.ncbi.nlm.nih.gov/pubmed/22809148
http://dx.doi.org/10.1186/1471-2342-12-16
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author Galinovic, Ivana
Ostwaldt, Ann-Christin
Soemmer, Carina
Bros, Helena
Hotter, Benjamin
Brunecker, Peter
Fiebach, Jochen B
author_facet Galinovic, Ivana
Ostwaldt, Ann-Christin
Soemmer, Carina
Bros, Helena
Hotter, Benjamin
Brunecker, Peter
Fiebach, Jochen B
author_sort Galinovic, Ivana
collection PubMed
description BACKGROUND: In perfusion magnetic resonance imaging a manual approach to delineation of regions of interest is, due to rater bias and time intensive operator input, clinically less favorable than an automated approach would be. The goal of our study was to compare the performances of these approaches. METHODS: Using Stroketool, PMA and Perfscape/Neuroscape perfusion maps of cerebral blood flow, mean transit time and Tmax were created for 145 patients with acute ischemic stroke. Volumes of hypoperfused tissue were calculated using both a manual and an automated protocol, and the results compared between methods. RESULTS: The median difference between the automatically and manually derived volumes was up to 210 ml in Perfscape/Neuroscape, 123 ml in PMA and 135 ml in Stroketool. Correlation coefficients between perfusion volumes and radiological and clinical outcome were much lower for the automatic volumes than for the manually derived ones. CONCLUSIONS: The agreement of the two methods was very poor, with the automated use producing falsely exaggerated volumes of hypoperfused tissue. Software improvements are necessary to enable highly automated protocols to credibly assess perfusion deficits.
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spelling pubmed-34230152012-08-21 Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software Galinovic, Ivana Ostwaldt, Ann-Christin Soemmer, Carina Bros, Helena Hotter, Benjamin Brunecker, Peter Fiebach, Jochen B BMC Med Imaging Research Article BACKGROUND: In perfusion magnetic resonance imaging a manual approach to delineation of regions of interest is, due to rater bias and time intensive operator input, clinically less favorable than an automated approach would be. The goal of our study was to compare the performances of these approaches. METHODS: Using Stroketool, PMA and Perfscape/Neuroscape perfusion maps of cerebral blood flow, mean transit time and Tmax were created for 145 patients with acute ischemic stroke. Volumes of hypoperfused tissue were calculated using both a manual and an automated protocol, and the results compared between methods. RESULTS: The median difference between the automatically and manually derived volumes was up to 210 ml in Perfscape/Neuroscape, 123 ml in PMA and 135 ml in Stroketool. Correlation coefficients between perfusion volumes and radiological and clinical outcome were much lower for the automatic volumes than for the manually derived ones. CONCLUSIONS: The agreement of the two methods was very poor, with the automated use producing falsely exaggerated volumes of hypoperfused tissue. Software improvements are necessary to enable highly automated protocols to credibly assess perfusion deficits. BioMed Central 2012-07-18 /pmc/articles/PMC3423015/ /pubmed/22809148 http://dx.doi.org/10.1186/1471-2342-12-16 Text en Copyright ©2012 Galinovic et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Galinovic, Ivana
Ostwaldt, Ann-Christin
Soemmer, Carina
Bros, Helena
Hotter, Benjamin
Brunecker, Peter
Fiebach, Jochen B
Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
title Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
title_full Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
title_fullStr Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
title_full_unstemmed Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
title_short Automated vs manual delineations of regions of interest- a comparison in commercially available perfusion MRI software
title_sort automated vs manual delineations of regions of interest- a comparison in commercially available perfusion mri software
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423015/
https://www.ncbi.nlm.nih.gov/pubmed/22809148
http://dx.doi.org/10.1186/1471-2342-12-16
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