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Incidental renal cell carcinoma presenting in a renal transplant recipient with autosomal dominant polycystic kidney disease: a case report

INTRODUCTION: We report an instructive case of incidental renal cell carcinoma in a patient with autosomal dominant polycystic kidney disease who underwent simultaneous bilateral native nephrectomy and living donor renal transplantation. CASE PRESENTATION: A 57-year-old Asian man with end-stage kidn...

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Detalles Bibliográficos
Autores principales: Misumi, Toshihiro, Ide, Kentaro, Onoe, Takashi, Banshodani, Masataka, Tazawa, Hirofumi, Teraoka, Yoshifumi, Hotta, Ryuichi, Yamashita, Masahiro, Tashiro, Hirotaka, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423017/
https://www.ncbi.nlm.nih.gov/pubmed/22691223
http://dx.doi.org/10.1186/1752-1947-6-154
Descripción
Sumario:INTRODUCTION: We report an instructive case of incidental renal cell carcinoma in a patient with autosomal dominant polycystic kidney disease who underwent simultaneous bilateral native nephrectomy and living donor renal transplantation. CASE PRESENTATION: A 57-year-old Asian man with end-stage kidney disease due to autosomal dominant polycystic kidney disease received a living kidney graft from his brother. Because of recurrent infection, chronic pain and enlarged kidneys, he underwent a bilateral nephrectomy with concomitant renal transplantation. The total weight of the removed kidneys was 6kg; the maximal diameter of the larger kidney was 28cm. His left kidney had a 1cm diameter tumor. Pathology indicated papillary renal cell carcinoma. At the time of this report, the transplant kidney function was normal with no evidence of local recurrence or distant metastasis. CONCLUSION: This case shows and reinforces the importance of considering the possibility of an occult malignancy in the native kidneys of patients with autosomal dominant polycystic kidney disease. Simultaneous bilateral native nephrectomy should be considered in these renal transplant recipients not only for preventing the development of adverse symptoms but also for detecting an occult malignancy.