Cargando…

A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis

BACKGROUND: Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs). We reported previously that blocking EMMPRIN activity reduced neuroinflammation and severity of disease in an animal model of multiple scl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agrawal, Smriti M, Silva, Claudia, Wang, Janet, Tong, Jade Pui-Wai, Yong, V Wee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423076/ https://www.ncbi.nlm.nih.gov/pubmed/22480370 http://dx.doi.org/10.1186/1742-2094-9-64

Ejemplares similares

Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid
por: Kaushik, Deepak K., et al.
Publicado: (2016)

Role of emmprin in endometrial cancer
por: Nakamura, Keiichiro, et al.
Publicado: (2012)

S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis: S-nitrosylation of EMMPRIN influences liver fibrosis
por: Zhu, Xinyan, et al.
Publicado: (2023)

EMMPRIN Expression in Oral Squamous Cell Carcinomas: Correlation with Tumor Proliferation and Patient Survival
por: Monteiro, Luís Silva, et al.
Publicado: (2014)

The role of EMMPRIN expression in ovarian epithelial carcinomas
por: Zhao, Yang, et al.
Publicado: (2013)

EMMPRIN expression is associated with metastatic progression in osteosarcoma
por: Kim, Han-Soo, et al.
Publicado: (2021)

Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts
por: Hasaneen, Nadia A., et al.
Publicado: (2016)

Functional Relevance of Protein Glycosylation to the Pro-Inflammatory Effects of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) on Monocytes/Macrophages
por: Ge, Heng, et al.
Publicado: (2015)

Emmprin and KSHV: New partners in viral cancer pathogenesis
por: Dai, Lu, et al.
Publicado: (2013)

EMMPRIN Is an Independent Negative Prognostic Factor for Patients with Astrocytic Glioma
por: Tian, Li, et al.
Publicado: (2013)

EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomas
por: Tsai, Wen-Chiuan, et al.
Publicado: (2013)

Inducing regulated necrosis and shifting macrophage polarization with anti‐EMMPRIN antibody (161‐pAb) and complement factors
por: Hijaze, Nizar, et al.
Publicado: (2020)

EMMPRIN Promotes Angiogenesis, Proliferation, Invasion and Resistance to Sunitinib in Renal Cell Carcinoma, and Its Level Predicts Patient Outcome
por: Sato, Mototaka, et al.
Publicado: (2013)

Environmental factors and their regulation of immunity in multiple sclerosis
por: Koch, Marcus W., et al.
Publicado: (2013)

Increased Expression of EMMPRIN and VEGF in the Rat Brain after Gamma Irradiation
por: Wei, Ming, et al.
Publicado: (2012)

Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis
por: Huang, Zhiquan, et al.
Publicado: (2014)

Tumor cell-macrophage interactions increase angiogenesis through secretion of EMMPRIN
por: Amit-Cohen, Bat-Chen, et al.
Publicado: (2013)

Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease
por: von Ungern-Sternberg, Saskia N. I., et al.
Publicado: (2018)

Soluble EMMPRIN levels discriminate aortic ectasia in Marfan syndrome patients
por: Rurali, Erica, et al.
Publicado: (2019)

The role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis
por: Rahat, Michal A., et al.
Publicado: (2020)

Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN
por: Menck, Kerstin, et al.
Publicado: (2015)

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts
por: Kawakami, Takehito, et al.
Publicado: (2011)

EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer
por: Boye, K, et al.
Publicado: (2012)

EMMPRIN-Targeted Magnetic Nanoparticles for In Vivo Visualization and Regression of Acute Myocardial Infarction
por: Cuadrado, Irene, et al.
Publicado: (2016)

EMMPRIN contributes to the in vitro invasion of human salivary adenoid cystic carcinoma cells
por: YANG, XINJIE, et al.
Publicado: (2011)

Inhibition of EMMPRIN by microRNA-124 suppresses the growth, invasion and tumorigenicity of gliomas
por: Song, Yanbin, et al.
Publicado: (2021)

The Effects of EMMPRIN/CD147 on Late Function and Histopathological Lesions of the Renal Graft
por: Nalewajska, Magdalena, et al.
Publicado: (2022)

Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play
por: Chuliá-Peris, Lourdes, et al.
Publicado: (2022)

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner
por: Jackson, Hannah K., et al.
Publicado: (2023)

Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders
por: Tong, Ming, et al.
Publicado: (2011)

CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis
por: Xin, Xiaoyan, et al.
Publicado: (2016)

EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke
por: Patrizz, Anthony, et al.
Publicado: (2020)

EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF
por: Khayati, Farah, et al.
Publicado: (2015)

The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies
por: Fan, Hengwei, et al.
Publicado: (2017)

EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions
por: Varadarajan, Saranya, et al.
Publicado: (2020)

MBRS-28. EXOSOMES DRIVE MEDULLOBLASTOMA METASTASIS IN A MMP2 AND EMMPRIN DEPENDENT MANNER
por: Jackson, Hannah K, et al.
Publicado: (2020)

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity
por: Kraft, Andrew D., et al.
Publicado: (2011)

Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse
por: Johnson, Simon C., et al.
Publicado: (2019)

EMMPRIN/CD147 up-regulates urokinase-type plasminogen activator: implications in oral tumor progression
por: Lescaille, Géraldine, et al.
Publicado: (2012)

Atorvastatin attenuates plaque vulnerability by downregulation of EMMPRIN expression via COX-2/PGE2 pathway
por: Liang, Xing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_56atah0icv81bdmb192hunkhv7