Co-Occurrence of TDP-43 Mislocalization with Reduced Activity of an RNA Editing Enzyme, ADAR2, in Aged Mouse Motor Neurons

TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase acting on RNA 2 (ADAR2) in the motor neurons of sp...

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Detalles Bibliográficos
Autores principales: Hideyama, Takuto, Teramoto, Sayaka, Hachiga, Kosuke, Yamashita, Takenari, Kwak, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423340/
https://www.ncbi.nlm.nih.gov/pubmed/22916266
http://dx.doi.org/10.1371/journal.pone.0043469

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