Cargando…

Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study

BACKGROUND: To examine ethnic differences in cardiometabolic risk profile in early age, and explore whether such differences can be explained by differences in body mass index (BMI) or waist circumference (WC). METHOD: Anthropometric measurements, blood pressure and (in a subsample) fasting blood we...

Descripción completa

Detalles Bibliográficos
Autores principales: de Hoog, Marieke L. A., van Eijsden, Manon, Stronks, Karien, Gemke, Reinoud J. B. J., Vrijkotte, Tanja G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423381/
https://www.ncbi.nlm.nih.gov/pubmed/22916294
http://dx.doi.org/10.1371/journal.pone.0043667
_version_ 1782241098799775744
author de Hoog, Marieke L. A.
van Eijsden, Manon
Stronks, Karien
Gemke, Reinoud J. B. J.
Vrijkotte, Tanja G. M.
author_facet de Hoog, Marieke L. A.
van Eijsden, Manon
Stronks, Karien
Gemke, Reinoud J. B. J.
Vrijkotte, Tanja G. M.
author_sort de Hoog, Marieke L. A.
collection PubMed
description BACKGROUND: To examine ethnic differences in cardiometabolic risk profile in early age, and explore whether such differences can be explained by differences in body mass index (BMI) or waist circumference (WC). METHOD: Anthropometric measurements, blood pressure and (in a subsample) fasting blood were collected during a health check of 2,509 children aged 5–6 years. Four ethnic groups were distinguished: Dutch (n = 2,008; blood n = 1,300), African descent (n = 199; blood n = 105), Turkish (n = 108; blood n = 57) and Moroccan (n = 194; blood n = 94). Ethnic differences in diastolic and systolic blood pressure (DBP/SBP), fasting glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were determined and the explanatory role of BMI and WC was examined with regression analysis. RESULTS: After adjustment for confounders, African descent children showed higher DBP (β2.22 mmHg; 95%CI:1.09–3.36) and HDL levels (β:0.09 mmol/l; 95%CI:0.03–0.16) compared to Dutch children (reference group). Turkish children showed higher SBP (β:1.89 mmHg; 95%CI:0.25–3.54), DBP (β:2.62 mmHg; 95%CI:1.11–4.13), glucose (β:0.12 mmol/L; 95%CI:0.00–0.25) and triglyceride levels (β:0.13 mmol/L; 95%CI:0.02–0.25). Higher BMI values were found in all non–Dutch groups (differences ranged from 0.53–1.03 kg/m(2)) and higher WC in Turkish (β:1.68 cm; 95%CI:0.99–2.38) and Moroccan (β:1.65 cm; 95%CI:1.11–2.19) children. BMI and WC partly explained the higher SBP/DBP and triglyceride levels in Turkish children. CONCLUSION: Ethnic differences in cardiometabolic profile exist early in life and are partly explained by differences in BMI and WC. African children showed favourable HDL levels and Turkish children the most unfavourable overall profile, whereas their Moroccan peers have less increased cardiometabolic risk in spite of their high BMI and WC.
format Online
Article
Text
id pubmed-3423381
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-34233812012-08-22 Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study de Hoog, Marieke L. A. van Eijsden, Manon Stronks, Karien Gemke, Reinoud J. B. J. Vrijkotte, Tanja G. M. PLoS One Research Article BACKGROUND: To examine ethnic differences in cardiometabolic risk profile in early age, and explore whether such differences can be explained by differences in body mass index (BMI) or waist circumference (WC). METHOD: Anthropometric measurements, blood pressure and (in a subsample) fasting blood were collected during a health check of 2,509 children aged 5–6 years. Four ethnic groups were distinguished: Dutch (n = 2,008; blood n = 1,300), African descent (n = 199; blood n = 105), Turkish (n = 108; blood n = 57) and Moroccan (n = 194; blood n = 94). Ethnic differences in diastolic and systolic blood pressure (DBP/SBP), fasting glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were determined and the explanatory role of BMI and WC was examined with regression analysis. RESULTS: After adjustment for confounders, African descent children showed higher DBP (β2.22 mmHg; 95%CI:1.09–3.36) and HDL levels (β:0.09 mmol/l; 95%CI:0.03–0.16) compared to Dutch children (reference group). Turkish children showed higher SBP (β:1.89 mmHg; 95%CI:0.25–3.54), DBP (β:2.62 mmHg; 95%CI:1.11–4.13), glucose (β:0.12 mmol/L; 95%CI:0.00–0.25) and triglyceride levels (β:0.13 mmol/L; 95%CI:0.02–0.25). Higher BMI values were found in all non–Dutch groups (differences ranged from 0.53–1.03 kg/m(2)) and higher WC in Turkish (β:1.68 cm; 95%CI:0.99–2.38) and Moroccan (β:1.65 cm; 95%CI:1.11–2.19) children. BMI and WC partly explained the higher SBP/DBP and triglyceride levels in Turkish children. CONCLUSION: Ethnic differences in cardiometabolic profile exist early in life and are partly explained by differences in BMI and WC. African children showed favourable HDL levels and Turkish children the most unfavourable overall profile, whereas their Moroccan peers have less increased cardiometabolic risk in spite of their high BMI and WC. Public Library of Science 2012-08-20 /pmc/articles/PMC3423381/ /pubmed/22916294 http://dx.doi.org/10.1371/journal.pone.0043667 Text en © 2012 de Hoog et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
de Hoog, Marieke L. A.
van Eijsden, Manon
Stronks, Karien
Gemke, Reinoud J. B. J.
Vrijkotte, Tanja G. M.
Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study
title Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study
title_full Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study
title_fullStr Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study
title_full_unstemmed Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study
title_short Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study
title_sort ethnic differences in cardiometabolic risk profile at age 5–6 years: the abcd study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423381/
https://www.ncbi.nlm.nih.gov/pubmed/22916294
http://dx.doi.org/10.1371/journal.pone.0043667
work_keys_str_mv AT dehoogmariekela ethnicdifferencesincardiometabolicriskprofileatage56yearstheabcdstudy
AT vaneijsdenmanon ethnicdifferencesincardiometabolicriskprofileatage56yearstheabcdstudy
AT stronkskarien ethnicdifferencesincardiometabolicriskprofileatage56yearstheabcdstudy
AT gemkereinoudjbj ethnicdifferencesincardiometabolicriskprofileatage56yearstheabcdstudy
AT vrijkottetanjagm ethnicdifferencesincardiometabolicriskprofileatage56yearstheabcdstudy