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HTLV-I Tax Increases Genetic Instability by Inducing DNA Double Strand Breaks during DNA Replication and Switching Repair to NHEJ

BACKGROUND: Appropriate responses to damaged DNA are indispensible for preserving genome stability and preventing cancer. Tumor viruses often target DNA repair machinery to achieve transformation. The Human T-cell leukemia virus type I (HTLV-I) is the only known transforming human retrovirus and the...

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Detalles Bibliográficos
Autores principales:	Baydoun, Hicham H., Bai, Xue Tao, Shelton, Shary, Nicot, Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423393/ https://www.ncbi.nlm.nih.gov/pubmed/22916124 http://dx.doi.org/10.1371/journal.pone.0042226

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