Proteoglycan metabolism, cell death and Kashin-Beck Disease

Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of art...

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Autores principales: Li, Siyuan, Cao, Junling, Caterson, Bruce, Hughes, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423566/
https://www.ncbi.nlm.nih.gov/pubmed/22733148
http://dx.doi.org/10.1007/s10719-012-9421-2
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author Li, Siyuan
Cao, Junling
Caterson, Bruce
Hughes, Clare E.
author_facet Li, Siyuan
Cao, Junling
Caterson, Bruce
Hughes, Clare E.
author_sort Li, Siyuan
collection PubMed
description Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan metabolism and loss of proteoglycans in articular cartilage from KBD patients has been observed. In this mini-review, we discuss the close relationship between chondrocyte death including necrosis and loss of proteoglycan, and its potential mechanism during KBD onset and development, which may provide new clues for KBD research.
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spelling pubmed-34235662012-08-22 Proteoglycan metabolism, cell death and Kashin-Beck Disease Li, Siyuan Cao, Junling Caterson, Bruce Hughes, Clare E. Glycoconj J Article Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan metabolism and loss of proteoglycans in articular cartilage from KBD patients has been observed. In this mini-review, we discuss the close relationship between chondrocyte death including necrosis and loss of proteoglycan, and its potential mechanism during KBD onset and development, which may provide new clues for KBD research. Springer US 2012-06-26 2012 /pmc/articles/PMC3423566/ /pubmed/22733148 http://dx.doi.org/10.1007/s10719-012-9421-2 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Li, Siyuan
Cao, Junling
Caterson, Bruce
Hughes, Clare E.
Proteoglycan metabolism, cell death and Kashin-Beck Disease
title Proteoglycan metabolism, cell death and Kashin-Beck Disease
title_full Proteoglycan metabolism, cell death and Kashin-Beck Disease
title_fullStr Proteoglycan metabolism, cell death and Kashin-Beck Disease
title_full_unstemmed Proteoglycan metabolism, cell death and Kashin-Beck Disease
title_short Proteoglycan metabolism, cell death and Kashin-Beck Disease
title_sort proteoglycan metabolism, cell death and kashin-beck disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423566/
https://www.ncbi.nlm.nih.gov/pubmed/22733148
http://dx.doi.org/10.1007/s10719-012-9421-2
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AT hughesclaree proteoglycanmetabolismcelldeathandkashinbeckdisease

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