Genetic markers in oligodendroglial tumours

BACKGROUND: Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5–20% of all gliomas. CONCLUSIONS: Oligodendroglial tumours with 1p and 19q loss demonstrate a bett...

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Detalles Bibliográficos
Autores principales: Velnar, Tomaz, Smrdel, Uros, Popovic, Mara, Bunc, Gorazd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita, Warsaw 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423675/
https://www.ncbi.nlm.nih.gov/pubmed/22933885
http://dx.doi.org/10.2478/v10019-010-0007-y
Descripción
Sumario:BACKGROUND: Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5–20% of all gliomas. CONCLUSIONS: Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment. Additionally, 1p and 19q loss is a marker of clinical utility, helping to assess tumour sensitivity to chemotherapy and harbouring the potential for improving the diagnosis and survival of oligodendroglioma patients as well as future clinical practice.

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