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Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
BACKGROUND: Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT. We describe the case of a 44-year-old man with a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Versita, Warsaw
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423677/ https://www.ncbi.nlm.nih.gov/pubmed/22933892 http://dx.doi.org/10.2478/v10019-010-0005-0 |
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author | Zhou, Yaolin Boardman, Lisa A. Miller, Robert C. |
author_facet | Zhou, Yaolin Boardman, Lisa A. Miller, Robert C. |
author_sort | Zhou, Yaolin |
collection | PubMed |
description | BACKGROUND: Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. CONCLUSIONS: This case underscores the importance of following cancer-screening guidelines. |
format | Online Article Text |
id | pubmed-3423677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Versita, Warsaw |
record_format | MEDLINE/PubMed |
spelling | pubmed-34236772012-08-29 Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines Zhou, Yaolin Boardman, Lisa A. Miller, Robert C. Radiol Oncol Case Report BACKGROUND: Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. CONCLUSIONS: This case underscores the importance of following cancer-screening guidelines. Versita, Warsaw 2010-03-18 2010-03 /pmc/articles/PMC3423677/ /pubmed/22933892 http://dx.doi.org/10.2478/v10019-010-0005-0 Text en Copyright © by Association of Radiology & Oncology http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Case Report Zhou, Yaolin Boardman, Lisa A. Miller, Robert C. Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
title | Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
title_full | Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
title_fullStr | Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
title_full_unstemmed | Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
title_short | Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
title_sort | genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423677/ https://www.ncbi.nlm.nih.gov/pubmed/22933892 http://dx.doi.org/10.2478/v10019-010-0005-0 |
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