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Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines

BACKGROUND: Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT. We describe the case of a 44-year-old man with a...

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Detalles Bibliográficos
Autores principales: Zhou, Yaolin, Boardman, Lisa A., Miller, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita, Warsaw 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423677/
https://www.ncbi.nlm.nih.gov/pubmed/22933892
http://dx.doi.org/10.2478/v10019-010-0005-0
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author Zhou, Yaolin
Boardman, Lisa A.
Miller, Robert C.
author_facet Zhou, Yaolin
Boardman, Lisa A.
Miller, Robert C.
author_sort Zhou, Yaolin
collection PubMed
description BACKGROUND: Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. CONCLUSIONS: This case underscores the importance of following cancer-screening guidelines.
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spelling pubmed-34236772012-08-29 Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines Zhou, Yaolin Boardman, Lisa A. Miller, Robert C. Radiol Oncol Case Report BACKGROUND: Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. CONCLUSIONS: This case underscores the importance of following cancer-screening guidelines. Versita, Warsaw 2010-03-18 2010-03 /pmc/articles/PMC3423677/ /pubmed/22933892 http://dx.doi.org/10.2478/v10019-010-0005-0 Text en Copyright © by Association of Radiology & Oncology http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Case Report
Zhou, Yaolin
Boardman, Lisa A.
Miller, Robert C.
Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
title Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
title_full Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
title_fullStr Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
title_full_unstemmed Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
title_short Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
title_sort genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423677/
https://www.ncbi.nlm.nih.gov/pubmed/22933892
http://dx.doi.org/10.2478/v10019-010-0005-0
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