Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer

BACKGROUND: Some tumour suppressor genes (BRCA2) and mismatch repair genes (MSH2, MLH1) are correlated with an increased risk for male breast cancer. CASE REPORT: Our patient developed secondary breast cancer after the treatment for Hodgkin’s disease in childhood. DNA was isolated from the patients’...

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Autores principales: Vodusek, Ana Lina, Novakovic, Srdjan, Stegel, Vida, Jereb, Berta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita, Warsaw 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423752/
https://www.ncbi.nlm.nih.gov/pubmed/22933969
http://dx.doi.org/10.2478/v10019-011-0031-6
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author Vodusek, Ana Lina
Novakovic, Srdjan
Stegel, Vida
Jereb, Berta
author_facet Vodusek, Ana Lina
Novakovic, Srdjan
Stegel, Vida
Jereb, Berta
author_sort Vodusek, Ana Lina
collection PubMed
description BACKGROUND: Some tumour suppressor genes (BRCA2) and mismatch repair genes (MSH2, MLH1) are correlated with an increased risk for male breast cancer. CASE REPORT: Our patient developed secondary breast cancer after the treatment for Hodgkin’s disease in childhood. DNA was isolated from the patients’ blood and screened for mutations, polymorphisms and variants in BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes. We found no mutations but common polymorphisms, and three variants in mismatch repair genes. CONCLUSIONS: Nucleotide variants c.2006-6T>C and p.G322D in MSH2 might be correlated with male breast cancer.
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spelling pubmed-34237522012-08-29 Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer Vodusek, Ana Lina Novakovic, Srdjan Stegel, Vida Jereb, Berta Radiol Oncol Case Report BACKGROUND: Some tumour suppressor genes (BRCA2) and mismatch repair genes (MSH2, MLH1) are correlated with an increased risk for male breast cancer. CASE REPORT: Our patient developed secondary breast cancer after the treatment for Hodgkin’s disease in childhood. DNA was isolated from the patients’ blood and screened for mutations, polymorphisms and variants in BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes. We found no mutations but common polymorphisms, and three variants in mismatch repair genes. CONCLUSIONS: Nucleotide variants c.2006-6T>C and p.G322D in MSH2 might be correlated with male breast cancer. Versita, Warsaw 2011-09-22 /pmc/articles/PMC3423752/ /pubmed/22933969 http://dx.doi.org/10.2478/v10019-011-0031-6 Text en Copyright © by Association of Radiology & Oncology http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Case Report
Vodusek, Ana Lina
Novakovic, Srdjan
Stegel, Vida
Jereb, Berta
Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer
title Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer
title_full Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer
title_fullStr Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer
title_full_unstemmed Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer
title_short Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancer
title_sort genotyping of brca1, brca2, p53, cdkn2a, mlh1 and msh2 genes in a male patient with secondary breast cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423752/
https://www.ncbi.nlm.nih.gov/pubmed/22933969
http://dx.doi.org/10.2478/v10019-011-0031-6
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