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Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture
[Image: see text] Many small molecules, including bioactive molecules and approved drugs, spontaneously form colloidal aggregates in aqueous solution at micromolar concentrations. Though it is widely accepted that aggregation leads to artifacts in screens for ligands of soluble proteins, the effects...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423826/ https://www.ncbi.nlm.nih.gov/pubmed/22625864 http://dx.doi.org/10.1021/cb300189b |