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Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans

Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham...

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Autores principales: Vidal, Adriana C., Grant, Delores J., Williams, Christina D., Masko, Elizabeth, Allott, Emma H., Shuler, Kathryn, McPhail, Megan, Gaines, Alexis, Calloway, Elizabeth, Gerber, Leah, Chi, Jen-Tsan, Freedland, Stephen J., Hoyo, Cathrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423941/
https://www.ncbi.nlm.nih.gov/pubmed/22927849
http://dx.doi.org/10.1155/2012/957467
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author Vidal, Adriana C.
Grant, Delores J.
Williams, Christina D.
Masko, Elizabeth
Allott, Emma H.
Shuler, Kathryn
McPhail, Megan
Gaines, Alexis
Calloway, Elizabeth
Gerber, Leah
Chi, Jen-Tsan
Freedland, Stephen J.
Hoyo, Cathrine
author_facet Vidal, Adriana C.
Grant, Delores J.
Williams, Christina D.
Masko, Elizabeth
Allott, Emma H.
Shuler, Kathryn
McPhail, Megan
Gaines, Alexis
Calloway, Elizabeth
Gerber, Leah
Chi, Jen-Tsan
Freedland, Stephen J.
Hoyo, Cathrine
author_sort Vidal, Adriana C.
collection PubMed
description Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004–2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer. Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1–3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32– 5.73). The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR = 6.7; 95%CI = 1.6–27.8), compared to MTHFR A1298A noncarrier men (OR = 0.9; 95%CI = 0.24–3.92) (p-interaction = 0.045). There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk. Larger studies are required to validate these findings.
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spelling pubmed-34239412012-08-27 Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans Vidal, Adriana C. Grant, Delores J. Williams, Christina D. Masko, Elizabeth Allott, Emma H. Shuler, Kathryn McPhail, Megan Gaines, Alexis Calloway, Elizabeth Gerber, Leah Chi, Jen-Tsan Freedland, Stephen J. Hoyo, Cathrine J Cancer Epidemiol Research Article Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004–2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer. Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1–3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32– 5.73). The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR = 6.7; 95%CI = 1.6–27.8), compared to MTHFR A1298A noncarrier men (OR = 0.9; 95%CI = 0.24–3.92) (p-interaction = 0.045). There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk. Larger studies are required to validate these findings. Hindawi Publishing Corporation 2012 2012-08-09 /pmc/articles/PMC3423941/ /pubmed/22927849 http://dx.doi.org/10.1155/2012/957467 Text en Copyright © 2012 Adriana C. Vidal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vidal, Adriana C.
Grant, Delores J.
Williams, Christina D.
Masko, Elizabeth
Allott, Emma H.
Shuler, Kathryn
McPhail, Megan
Gaines, Alexis
Calloway, Elizabeth
Gerber, Leah
Chi, Jen-Tsan
Freedland, Stephen J.
Hoyo, Cathrine
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
title Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
title_full Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
title_fullStr Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
title_full_unstemmed Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
title_short Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
title_sort associations between intake of folate, methionine, and vitamins b-12, b-6 and prostate cancer risk in american veterans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423941/
https://www.ncbi.nlm.nih.gov/pubmed/22927849
http://dx.doi.org/10.1155/2012/957467
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