Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In this study, we hypothesize that tobacco smokers are su...

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Detalles Bibliográficos
Autores principales: Guzmán, Leda, Depix, María Soledad, Salinas, Ana María, Roldán, Rosa, Aguayo, Francisco, Silva, Alejandra, Vinet, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424112/
https://www.ncbi.nlm.nih.gov/pubmed/22818553
http://dx.doi.org/10.1186/1746-1596-7-87

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