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Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1

BACKGROUND: Prolonged exposure to hyperoxia in neonates can cause hyperoxic acute lung injury (HALI), which is characterized by increased pulmonary permeability and diffuse infiltration of various inflammatory cells. Disruption of the epithelial barrier may lead to altered pulmonary permeability and...

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Detalles Bibliográficos
Autores principales: You, Kai, Xu, Xuewen, Fu, Jianhua, Xu, Shuyan, Yue, Xiaohong, Yu, Zhiling, Xue, Xindong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424121/
https://www.ncbi.nlm.nih.gov/pubmed/22559818
http://dx.doi.org/10.1186/1465-9921-13-36