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Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008

BACKGROUND: Streptomyces hygroscopicus 5008 has been used for the production of the antifungal validamycin/jinggangmycin for more than 40 years. A high yield of validamycin is achieved by culturing the strain at 37°C, rather than at 30°C for normal growth and sporulation. The mechanism(s) of its the...

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Detalles Bibliográficos
Autores principales:	Wu, Hang, Qu, Shuang, Lu, Chenyang, Zheng, Huajun, Zhou, Xiufen, Bai, Linquan, Deng, Zixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424136/ https://www.ncbi.nlm.nih.gov/pubmed/22827618 http://dx.doi.org/10.1186/1471-2164-13-337

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