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Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement

BACKGROUND: Dengue viruses (DENV) are the most important arboviruses of humans and cause significant disease. Infection with DENV elicits antibody responses to the envelope glycoprotein, predominantly against immunodominant, cross-reactive, weakly-neutralizing epitopes. These weakly-neutralizing ant...

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Detalles Bibliográficos
Autores principales:	Hughes, Holly R, Crill, Wayne D, Chang, Gwong-Jen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424142/ https://www.ncbi.nlm.nih.gov/pubmed/22709350 http://dx.doi.org/10.1186/1743-422X-9-115

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