Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway

A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phospha...

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Detalles Bibliográficos
Autores principales: Perez-Gil, Jordi, Uros, Eva Maria, Sauret-Güeto, Susanna, Lois, L. Maria, Kirby, James, Nishimoto, Minobu, Baidoo, Edward E. K., Keasling, Jay D., Boronat, Albert, Rodriguez-Concepcion, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424233/
https://www.ncbi.nlm.nih.gov/pubmed/22928031
http://dx.doi.org/10.1371/journal.pone.0043775

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