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Intravenous Administration of Adenoviruses Targeting Transforming Growth Factor Beta Signaling Inhibits Established Bone Metastases in 4T1 Mouse Mammary Tumor Model in an Immunocompetent Syngeneic Host

We have examined the effect of adenoviruses expressing soluble transforming growth factor receptorII-Fc (sTGFβRIIFc) in a 4T1 mouse mammary tumor bone metastasis model using syngeneic BALB/c mice. Infection of 4T1 cells with a non-replicating adenovirus, Ad(E1-).sTβRFc, or with two oncolytic adenovi...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhenwei, Hu, Zebin, Gupta, Janhavi, Krimmel, Jeffrey, Gerseny, Helen, Berg, Arthur, Robbins, John, Du, Hongyan, Prabhakar, Bellur, Seth, Prem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424293/ https://www.ncbi.nlm.nih.gov/pubmed/22744210 http://dx.doi.org/10.1038/cgt.2012.41

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